PROGNOSTIC BIOMARKER FOR COLON CANCER

WIPO Patent Application WO/2019/049829

A1

Provided is a biomarker for predicting the prognosis of a colon cancer patient, and/or for determining the efficacy of an anticancer agent in a colon cancer patient. Provided is a biomarker for predicting the prognosis of a colon cancer patient and/or for determining the efficacy of an anticancer agent in a colon cancer patient, the biomarker comprising a GALNT6 protein or peptide fragment thereof, or a GALNT6 gene transcription product or a nucleic acid fragment thereof.

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OKAYAMA HIROKAZU (JP)
NODA MASARU (JP)
KONO KOJI (JP)

PCT/JP2018/032628

March 14, 2019

September 03, 2018

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UNIV FUKUSHIMA MEDICAL (JP)

G01N33/68; C12N9/10; C12N15/54; C12N15/65; C12Q1/6804; C12Q1/6813

NAKAMORI SHOJI ET AL.: "Development of tumor marker helpful in early diagnosis and prognosis of cancer", ANNUAL REPORT OF THE CANCER RESEARCH MINISTRY OF HEALTH- LABOUR AND WELFARE, vol. 2006, September 2007 (2007-09-01), pages 196 - 200
JAE-HYUN PARK ET AL.: "Identification of an 0-type glycosyltransferase(GALNT6) as a novel molecular target for breast cancer therapy", vol. 69 th, 23 August 2010 (2010-08-23), pages 274
MASARU NODA ET AL.: "Glycosyltransferase Gene Expression Identifies a Poor Prognostic Colorectal Cancer Subtype Associated with Mismatch Repair Deficiency and Incomplete Glycan Synthesis", CLINICAL CANCER RESEARCH, vol. 24, no. 18, 15 September 2018 (2018-09-15), pages 4468 - 4481, XP055581339, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-17-3533

HIRAKI & ASSOCIATES (JP)

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