Title:
PROGNOSTIC METHODS FOR CONGESTIVE HEART FAILURE
Document Type and Number:
WIPO Patent Application WO2005089045
Kind Code:
A3
Abstract:
Provided are methods for predicting survival outcome of an individual suffering from congestive heart failure. In accordance with the method, a patient's survival outcome is determined by taking into consideration the levels of two markers in combination, the combination being more predictive of survival than either marker alone. The markers include endothelin, atrial natriuretic peptide and brain natriuretic peptide, their precursors and fragments thereof. Individuals with congestive heart failure identified as having increased risk of mortality using the methods of the invention are appropriately targeted for more aggressive therapy.
Inventors:
KETELSLEGERS JEAN-MARIE (BE)
ROUSSEAU MICHEL (BE)
ROUSSEAU MICHEL (BE)
Application Number:
PCT/IB2005/002063
Publication Date:
July 20, 2006
Filing Date:
March 18, 2005
Export Citation:
Assignee:
UNIV CATHOLIQUE LOUVAIN (BE)
CLINIQUE UNIVERSITAIRES SAINT (BE)
KETELSLEGERS JEAN-MARIE (BE)
ROUSSEAU MICHEL (BE)
CLINIQUE UNIVERSITAIRES SAINT (BE)
KETELSLEGERS JEAN-MARIE (BE)
ROUSSEAU MICHEL (BE)
International Classes:
G01N33/68; G01N33/74
Other References:
ROUSSEAU MICHEL F ET AL: "Endothelial markers big endothelin-1 and endothelin-1 are better than natriuretic peptides to predict survival in severe congestive heart failure.", CIRCULATION, vol. 108, no. 17 Supplement, 28 October 2003 (2003-10-28), & AMERICAN HEART ASSOCIATION SCIENTIFIC SESSIONS 2003; ORLANDO, FL, USA; NOVEMBER 09-12, 2003, pages IV - 556, XP008057033, ISSN: 0009-7322
SELVAIS P L ET AL: "Direct comparison between endothelin-1, N-terminal proatrial natriuretic factor, and brain natriuretic peptide as prognostic markers of survival in congestive heart failure.", JOURNAL OF CARDIAC FAILURE. SEP 2000, vol. 6, no. 3, September 2000 (2000-09-01), pages 201 - 207, XP002358280, ISSN: 1071-9164
BERGER RUDOLF ET AL: "Prognostic power of neurohumoral parameters in chronic heart failure depends on clinical stage and observation period.", THE JOURNAL OF HEART AND LUNG TRANSPLANTATION : THE OFFICIAL PUBLICATION OF THE INTERNATIONAL SOCIETY FOR HEART TRANSPLANTATION. SEP 2003, vol. 22, no. 9, September 2003 (2003-09-01), pages 1037 - 1045, XP002358374, ISSN: 1053-2498
SELVAIS P L ET AL: "Cardiac natriuretic peptides for diagnosis and risk stratification in heart failure: influences of left ventricular dysfunction and coronary artery disease on cardiac hormonal activation.", EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. AUG 1998, vol. 28, no. 8, August 1998 (1998-08-01), pages 636 - 642, XP002358375, ISSN: 0014-2972
VALDEMARSSON S ET AL: "Relationships between plasma levels of catecholamines and neuropeptides and the survival time in patients with congestive heart failure.", JOURNAL OF INTERNAL MEDICINE. JUN 1994, vol. 235, no. 6, June 1994 (1994-06-01), pages 595 - 601, XP008057034, ISSN: 0954-6820
RUSKOAHO HEIKKI: "Cardiac hormones as diagnostic tools in heart failure.", ENDOCRINE REVIEWS. JUN 2003, vol. 24, no. 3, June 2003 (2003-06-01), pages 341 - 356, XP002303782, ISSN: 0163-769X
STANEK B ET AL: "Validation of big endothelin plasma levels compared with established neurohumoral markers in patients with severe chronic heart failure.", TRANSPLANTATION PROCEEDINGS. 1997 FEB-MAR, vol. 29, no. 1-2, February 1997 (1997-02-01), pages 595 - 596, XP008057059, ISSN: 0041-1345
HÜLSMANN M ET AL: "Value of cardiopulmonary exercise testing and big endothelin plasma levels to predict short-term prognosis of patients with chronic heart failure.", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 15 NOV 1998, vol. 32, no. 6, 15 November 1998 (1998-11-15), pages 1695 - 1700, XP002358458, ISSN: 0735-1097
SELVAIS P L ET AL: "Direct comparison between endothelin-1, N-terminal proatrial natriuretic factor, and brain natriuretic peptide as prognostic markers of survival in congestive heart failure.", JOURNAL OF CARDIAC FAILURE. SEP 2000, vol. 6, no. 3, September 2000 (2000-09-01), pages 201 - 207, XP002358280, ISSN: 1071-9164
BERGER RUDOLF ET AL: "Prognostic power of neurohumoral parameters in chronic heart failure depends on clinical stage and observation period.", THE JOURNAL OF HEART AND LUNG TRANSPLANTATION : THE OFFICIAL PUBLICATION OF THE INTERNATIONAL SOCIETY FOR HEART TRANSPLANTATION. SEP 2003, vol. 22, no. 9, September 2003 (2003-09-01), pages 1037 - 1045, XP002358374, ISSN: 1053-2498
SELVAIS P L ET AL: "Cardiac natriuretic peptides for diagnosis and risk stratification in heart failure: influences of left ventricular dysfunction and coronary artery disease on cardiac hormonal activation.", EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. AUG 1998, vol. 28, no. 8, August 1998 (1998-08-01), pages 636 - 642, XP002358375, ISSN: 0014-2972
VALDEMARSSON S ET AL: "Relationships between plasma levels of catecholamines and neuropeptides and the survival time in patients with congestive heart failure.", JOURNAL OF INTERNAL MEDICINE. JUN 1994, vol. 235, no. 6, June 1994 (1994-06-01), pages 595 - 601, XP008057034, ISSN: 0954-6820
RUSKOAHO HEIKKI: "Cardiac hormones as diagnostic tools in heart failure.", ENDOCRINE REVIEWS. JUN 2003, vol. 24, no. 3, June 2003 (2003-06-01), pages 341 - 356, XP002303782, ISSN: 0163-769X
STANEK B ET AL: "Validation of big endothelin plasma levels compared with established neurohumoral markers in patients with severe chronic heart failure.", TRANSPLANTATION PROCEEDINGS. 1997 FEB-MAR, vol. 29, no. 1-2, February 1997 (1997-02-01), pages 595 - 596, XP008057059, ISSN: 0041-1345
HÜLSMANN M ET AL: "Value of cardiopulmonary exercise testing and big endothelin plasma levels to predict short-term prognosis of patients with chronic heart failure.", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 15 NOV 1998, vol. 32, no. 6, 15 November 1998 (1998-11-15), pages 1695 - 1700, XP002358458, ISSN: 0735-1097
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