PROLINE DERIVATIVES AND USE THEREOF AS DRUGS

Title:

PROLINE DERIVATIVES AND USE THEREOF AS DRUGS

Document Type and Number:

WIPO Patent Application WO/2002/014271

Kind Code:

A1

Abstract:

The invention aims at providing compounds which exhibit therapeutic effects through the inhibition of DPP-IV and are satisfactory as drugs. The invention has been accomplished by finding that $g(g)-substituted proline derivatives of the general formula (I) exhibit potent DPP-IV inhibitory activities and improving the same in stability. [In the general formula, each symbol is as defined in the description.]

Inventors:

KITAJIMA HIROSHI (JP)
SAKASHITA HIROSHI (JP)
AKAHOSHI FUMIHIKO (JP)
HAYASHI YOSHIHARU (JP)

Application Number:

PCT/JP2001/006906

Publication Date:

February 21, 2002

Filing Date:

August 10, 2001

Export Citation:

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Assignee:

WELFIDE CORP (JP)
KITAJIMA HIROSHI (JP)
SAKASHITA HIROSHI (JP)
AKAHOSHI FUMIHIKO (JP)
HAYASHI YOSHIHARU (JP)

International Classes:

A61P1/02; A61P3/04; A61P3/10; A61P13/08; A61P17/00; A61P31/18; A61P35/04; A61P37/06; A61P43/00; C07D207/16; C07D401/14; C07D403/14; C07D413/14; C07D417/06; C07D417/14; C07D471/10; C07D487/04; C07D498/04; (IPC1-7): C07D207/16; C07D401/14; C07D417/14; C07D498/04; C07D487/04; A61K31/401; A61K31/454; A61K31/4439; A61K31/427; A61K31/4709; A61K31/5377; A61K31/438; A61K31/496; A61K31/506; A61K31/517; A61K31/5025; A61K31/551; A61P43/00; A61P3/10; A61P3/04; A61P31/18; A61P35/04; A61P17/00; A61P13/08; A61P1/02; A61P37/06

Domestic Patent References:

WO1999061431A1

1999-12-02

Other References: