Title:
PROMOTER SEQUENCE OF SPECIFIC PROMOTING GENE IN MAMMALIAN MUSCLE AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/160317
Kind Code:
A1
Abstract:
Provided is a chimeric promoter capable of specific expression in muscle tissue, comprising a muscle-specific transcription factor recognition binding site, a muscle-specific cis-regulatory module and a muscle-specific promoter. Also provided are an expression cassette, an expression vector and a virion comprising the chimeric promoter, and the therapeutic uses thereof.
Inventors:
LI HUAPENG (CN)
CHEN JUNLIN (CN)
ZHONG YUJIAN (CN)
BU YE (CN)
CHEN JUNLIN (CN)
ZHONG YUJIAN (CN)
BU YE (CN)
Application Number:
PCT/CN2023/073197
Publication Date:
August 31, 2023
Filing Date:
January 19, 2023
Export Citation:
Assignee:
PACKGENE BIOTECH CO LTD (CN)
International Classes:
A61K38/17; C12N15/113; A61P21/00; C12N5/10; C12N15/864
Domestic Patent References:
| WO2007061053A1 | 2007-05-31 | |||
| WO2021165353A1 | 2021-08-26 |
Foreign References:
| CN114231532A | 2022-03-25 | |||
| US20160340693A1 | 2016-11-24 |
Other References:
LI-SI QI, TONG HUI-LI, LI SHU-FENG, HU QIAN, YAN YUN-QIN: "The Study of Recombination of Bovine Desmin Gene Promoter", CHINESE JOURNAL OF ANIMAL AND VETERINARY SCIENCES, vol. 47, no. 12, 28 December 2016 (2016-12-28), pages 2405 - 2413, XP093088094
MALERBA ALBERTO, SIDOLI CHIARA, LU-NGUYEN NGOC, HERATH SHAN, LE HERON ANITA, ABDUL-RAZAK HAYDER, JARMIN SUSAN, VANDENDRIESSCHE THI: "Dose-Dependent Microdystrophin Expression Enhancement in Cardiac Muscle by a Cardiac-Specific Regulatory Element", HUMAN GENE THERAPY, MARY ANN LIEBERT, INC. PUBLISHERS, GB, vol. 32, no. 19-20, 1 October 2021 (2021-10-01), GB , pages 1138 - 1146, XP093087721, ISSN: 1043-0342, DOI: 10.1089/hum.2020.325
MALERBA ALBERTO, SIDOLI CHIARA, LU-NGUYEN NGOC, HERATH SHAN, LE HERON ANITA, ABDUL-RAZAK HAYDER, JARMIN SUSAN, VANDENDRIESSCHE THI: "Dose-Dependent Microdystrophin Expression Enhancement in Cardiac Muscle by a Cardiac-Specific Regulatory Element", HUMAN GENE THERAPY, MARY ANN LIEBERT, INC. PUBLISHERS, GB, vol. 32, no. 19-20, 1 October 2021 (2021-10-01), GB , pages 1138 - 1146, XP093087721, ISSN: 1043-0342, DOI: 10.1089/hum.2020.325
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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