TUMOR−SPECIFIC PROMOTER AND USE THEREOF

Title:

TUMOR−SPECIFIC PROMOTER AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2003/025190

Kind Code:

A1

Abstract:

A promoter domain of 1816 bp or 441 bp in the upstream side of exon 1B of IAI.3B gene has a specifically high promoter activity in ovarian cancer cells. An adenovirus having this promoter domAin inserted in the E1 domain thereof exhibits a specifically high cell proliferation inhibitory effect on ovarian cancer cells. Thus, it is efficacious in gene therapy for ovarian cancer.

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Inventors:

HAMADA KATSUYUKI (JP)

Application Number:

PCT/JP2002/000724

Publication Date:

March 27, 2003

Filing Date:

January 30, 2002

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Assignee:

PRIMMUNE K K (JP)
HAMADA KATSUYUKI (JP)

International Classes:

A61K35/76; A61K35/761; A61K48/00; C12N7/01; C12N15/85; C12N15/86; C12N15/861; (IPC1-7): C12N15/861; A61K48/00; C12N7/01

Domestic Patent References:

WO1998023779A1

1998-06-04

Other References:

DAVID F. BARKER ET AL.: "The BRCA1 and 1A1.3B promoters are parallel elements of a genomic duplication at 17q21", GENOMICS, vol. 38, no. 2, December 1996 (1996-12-01), pages 215 - 222, XP002950552
CARLA HEISE ET AL.: "Replication-selective adenoviruses as oncolytic agents", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 105, no. 7, April 2000 (2000-04-01), pages 847 - 851, XP002947267

Attorney, Agent or Firm:

Asamura, Kiyoshi (New Ohtemachi Bldg. 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo, JP)

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