Title:
PROPANOLAMINOMETHYLTETRALINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO2003048117
Kind Code:
A3
Abstract:
The invention concerns compounds of formula (I), wherein A is a group of formula (a) or (b), wherein: R represents a hydrogen or halogen atom, a -S(O)z(C1-C4)Alk wherein z is 0, 1 or 2, a -NHSO2(C1-C4)Alk, -SO2NH(C1-C4)Alk, -NHSO2-(C1-C4) Alk-phenyl or -NHSO2-phenyl group, said phenyl capable of bearing a halogen atom, a (C1-C4) Alk group or a (C1-C6)alkoxy group; R1 represents a hydrogen atom or a -(C1-C4)Alk, -CO(C1C4)Alk, -(C1-C4)Alk-phenyl or -CO-phenyl group, said phenyl capable of bearing a halogen atom or a -(C1-C4)Alk or (C1-C6)alkoxy group; R2 is a hydrogen atom, a -SO2(C1-C4)Alk, -SO2-(C1-C4)Alk-phenyl, -SO2-phenyl group, or a -(C1-C4)Alk group; X completes a saturated or unsaturated cycle of 5 to 8 atoms, capable of bearing one or two -(C1-C4) Alk groups and/or two carbonyl groups; R3 and R'3 represent each independently a hydrogen or halogen atom, a -(C1-C6)Alk, hydroxy, -CN, -(C1-C6)alkoxy, -COR4 or Y-CR8R9-COR4 group; Y represents O or CH2; R4 represents a hydroxy, (C1-C6) alkoxy or -NR5R6 group; R5 and R6 independently represent a hydrogen atom, a -(C1-C4)Alk, group, aryl or heteroaryl optionally substituted by a R7 group, aralkyl or heteroaralkyl optionally substituted by a R7 group; or R5 and R6, with the nitrogen atom which bears them, form a saturated or unsaturated cycle of 5 to 7 atoms optionally substituted by a R7 group; and R7 represents a hydrogen or halogen atom, a hydroxy, -(C1-C4)Alk, -(C1-C6)alkoxy, -NH(C1-C4)Alk, -N(C1-C4)Alk2, -COO(C1-C4)Alk, aralkyl or heteroaryl group; R8 and R9 independently represent a hydrogen atom or a -(C1-C4)Alk group; their salts or solvates, the pharmaceutical compositions containing them, a method for preparing them and synthesis intermediates.
Inventors:
BARZAGHI LAURA (IT)
CECCHI ROBERTO (IT)
VIVIANI NUNZIA (IT)
CECCHI ROBERTO (IT)
VIVIANI NUNZIA (IT)
Application Number:
PCT/FR2002/004129
Publication Date:
December 11, 2003
Filing Date:
December 02, 2002
Export Citation:
Assignee:
SANOFI SYNTHELABO (FR)
BARZAGHI LAURA (IT)
CECCHI ROBERTO (IT)
VIVIANI NUNZIA (IT)
BARZAGHI LAURA (IT)
CECCHI ROBERTO (IT)
VIVIANI NUNZIA (IT)
International Classes:
A61K31/138; A61K31/18; A61K31/357; A61P1/00; A61P1/04; A61P1/14; A61P3/04; A61P3/10; A61P15/00; C07D319/22; A61P15/06; A61P25/18; A61P25/24; A61P27/06; C07B53/00; C07C217/74; C07C311/08; (IPC1-7): C07C311/08; C07D319/18; A61K31/18; A61P1/04; A61P3/04; A61P3/10; A61P15/06; A61P25/24; A61P27/06
Foreign References:
| EP0375560A1 | 1990-06-27 | |||
| US4004028A | 1977-01-18 |
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