Title:
PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR ENDOMETRIOSIS OR ADENOMYOSIS
Document Type and Number:
WIPO Patent Application WO/2023/157895
Kind Code:
A1
Abstract:
The present invention pertains to a prophylactic, therapeutic or inhibitory agent for endometriosis, adenomyosis or dysmenorrhea, said prophylactic, therapeutic or inhibitory agent including a compound having a P2X4 receptor antagonistic action, or a pharmaceutically-acceptable salt thereof, as an effective ingredient.
Inventors:
TANIGUCHI FUMIAKI (JP)
NAKAMURA KAZUOMI (JP)
NAGATA HIROKI (JP)
IMAI TOSHIYASU (JP)
NAKAMURA KAZUOMI (JP)
NAGATA HIROKI (JP)
IMAI TOSHIYASU (JP)
Application Number:
PCT/JP2023/005351
Publication Date:
August 24, 2023
Filing Date:
February 16, 2023
Export Citation:
Assignee:
NAT UNIV CORP TOTTORI UNIV (JP)
NIPPON CHEMIPHAR CO (JP)
NIPPON CHEMIPHAR CO (JP)
International Classes:
A61K31/551; A61K45/00; A61P15/00; A61P43/00
Domestic Patent References:
| WO2010093061A1 | 2010-08-19 | |||
| WO2013105608A1 | 2013-07-18 | |||
| WO2022030428A1 | 2022-02-10 | |||
| WO2019045075A1 | 2019-03-07 |
Other References:
OSADA, HIROKI ET AL.: "P-28-6 Effects of a P2X4 receptor antagonist on endometriosis", JOURNAL OF JAPAN SOCIETY OF OBSTETRICS AND GYNECOLOGY, NIHON-SANKA-FUJINKA-GAKKAI, JP, vol. 74, no. Special Issue, 1 February 2022 (2022-02-01), JP , pages S - 362, XP009548750, ISSN: 0300-9165
TRAPERO CARLA, MARTÍN-SATUÉ MIREIA: "Purinergic Signaling in Endometriosis-Associated Pain", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 21, no. 22, 12 November 2020 (2020-11-12), Basel, CH , pages 8512, XP093059319, ISSN: 1661-6596, DOI: 10.3390/ijms21228512
NAGIRA KEI, TANIGUCHI FUMINORI, NAKAMURA KAZUOMI, TOKITA YOHEI, TSUCHIYA NAOKO, KHINE YIN MON, HARADA TASUKU: "Tokishakuyakusan, a Kampo medicine, attenuates endometriosis‐like lesions and hyperalgesia in murine with endometriosis‐like symptoms", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 82, no. 5, 1 November 2019 (2019-11-01), US , pages 1 - 8, XP093086257, ISSN: 1046-7408, DOI: 10.1111/aji.13182
TRAPERO CARLA, MARTÍN-SATUÉ MIREIA: "Purinergic Signaling in Endometriosis-Associated Pain", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 21, no. 22, 12 November 2020 (2020-11-12), Basel, CH , pages 8512, XP093059319, ISSN: 1661-6596, DOI: 10.3390/ijms21228512
NAGIRA KEI, TANIGUCHI FUMINORI, NAKAMURA KAZUOMI, TOKITA YOHEI, TSUCHIYA NAOKO, KHINE YIN MON, HARADA TASUKU: "Tokishakuyakusan, a Kampo medicine, attenuates endometriosis‐like lesions and hyperalgesia in murine with endometriosis‐like symptoms", AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 82, no. 5, 1 November 2019 (2019-11-01), US , pages 1 - 8, XP093086257, ISSN: 1046-7408, DOI: 10.1111/aji.13182
Attorney, Agent or Firm:
ASAKURA Eiji et al. (JP)
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