Title:
PROPHYLACTIC OR THERAPEUTIC AGENT FOR ALLERGIC OPHTHALMIC DISEASE OR ALLERGIC NASAL DISEASE COMPRISING TRICYCLIC TRIAZOLOBENZOAZEPINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2007/100079
Kind Code:
A1
Abstract:
Disclosed is a pharmaceutical composition for prevention or treatment of an allergic ophthalmic disease or an allergic nasal disease, which comprises 7,8-dimethoxy-4(5H),10-dioxo-1H- 1,2,3-triazolo[4,5-c][1]benzoazepine or 2-(1- isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy- 4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzoazepine, or a pharmacologically acceptable salt thereof. The pharmaceutical composition produces little adverse side effects and has a potent prophylactic effect and a potent therapeutic effect in a late phase where the treatment-resistance against an already available eye drop may be induced. The composition can be suitably used for topical administration.
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Inventors:
SHISHIKURA TAKASHI (JP)
INABA TSUNEYOSHI (JP)
HOSHINA YUKARI (JP)
AKABANE HIROTOMO (JP)
UCHIDA MITSUHIRO (JP)
INABA TSUNEYOSHI (JP)
HOSHINA YUKARI (JP)
AKABANE HIROTOMO (JP)
UCHIDA MITSUHIRO (JP)
Application Number:
PCT/JP2007/054008
Publication Date:
September 07, 2007
Filing Date:
March 02, 2007
Export Citation:
Assignee:
MEIJI SEIKA KAISHA (JP)
SHISHIKURA TAKASHI (JP)
INABA TSUNEYOSHI (JP)
HOSHINA YUKARI (JP)
AKABANE HIROTOMO (JP)
UCHIDA MITSUHIRO (JP)
SHISHIKURA TAKASHI (JP)
INABA TSUNEYOSHI (JP)
HOSHINA YUKARI (JP)
AKABANE HIROTOMO (JP)
UCHIDA MITSUHIRO (JP)
International Classes:
A61K31/55; A61P27/02; A61P27/16; A61P37/08; C07D487/04
Domestic Patent References:
| WO2004113343A1 | 2004-12-29 | |||
| WO2003055886A1 | 2003-07-10 | |||
| WO1999016770A1 | 1999-04-08 | |||
| WO1997000258A1 | 1997-01-03 | |||
| WO1995018130A1 | 1995-07-06 | |||
| WO1995018130A1 | 1995-07-06 | |||
| WO1999016770A1 | 1999-04-08 |
Foreign References:
| JP2006055706A | 2006-03-02 | |||
| JP2006055711A | 2006-03-02 | |||
| JP3290664B2 | 2002-06-10 | |||
| US5686442A | 1997-11-11 | |||
| JP3188482B2 | 2001-07-16 | |||
| US6372735B1 | 2002-04-16 |
Other References:
HANSEN I. ET AL.: "Mediators of inflammation in the early and the late phase of allergic rhinitis", CURR. OPIN. ALLERGY CLIN. IMMUNOL., vol. 4, 2004, pages 159 - 163
AZUMA KOZUE; OHNO SHIGEAKI ET AL.: "Arerugisei Ketsumaku Shikkan Gaisetsu (Outline of allergic conjunctival diseases", 2003, KANEHARA & CO., LTD., article "NEW MOOK Ganka (Ophthalmology); Arerugisei Gan Shikkan (Allergic ophthalmic diseases) 6", pages: 1 - 5
KING H.C. ET AL.: "Pharmacotherapy of allergic rhinitis", 2005, THIEME MEDICAL PUBLISHER, INC., article "Allergy in ENT Practice The basic guide 2nd", pages: 178 - 204
KRAMER M.F. ET AL.: "Nasal IL-16 and MIP-la in late-phase allergic response", ALLERGY AND ASTHMA PROC., vol. 22, 2001, pages 127 - 132
ECONOMIDES A; KALINER M.A.: "Allergic rhinitis", 2002, KALINER M.A. CURRENT MEDICINE, INC., article "Current Review of Rhinitis", pages: 35 - 51
HINGORANI M.; LIGHTMAN S.: "Ocular Allergy", 1997, BLACKWELL SCIENCE, INC., article "Allergy and Allergic Diseases", pages: 1645 - 1670
CIPRANDI G.B ET AL.: "Defrazacort protects against late-phase but early-phase reactions induced by the allergen-specific conjunctival provocation test", ALLERGY, vol. 48, 1993, pages 421 - 430
TAKAMURA ETSUKO, ARERUGISEI KETSUMAKU SHIKKAN NO MENO KAYUMI NO SEIIN TO CHIRYO, vol. 19, 2005, pages 444 - 449
BARNEY N.P.; GRAZIANO F.M. ET AL.: "Allergic and immunological diseases of eye, in Middleton's Allergy principles & practice", 2003, MOSBY, INC., pages: 1599 - 1617
BENSCH G.W. ET AL.: "Evaluation of cytokines in nasal secretions after nasal antigen challenge: lack of influence of antihistamines", ANN. ALLERGY ASTHMA IMMUNOL., vol. 88, 2002, pages 457 - 462
BEREGER W.E. ET AL.: "Efficacy of azelastine nasal spray in patients with an unsatisfactory response to loratadine", ANN. ALLERGY ASTHMA IMMUNOL., vol. 91, 2003, pages 205 - 211
LAFORCE C.F. ET AL.: "Efficacy of azelastine nasal spray in seasonal allergic rhinitis patients who remain symptomatic after treatment with fexofenadine", ANN. ALLERGY ASTHMA IMMUNOL., vol. 93, 2004, pages 154 - 159
DRAIN K.L.; LI J.T.C.: "Corticosteroids and their use in rhinitis", 2002, KALINER M.A. CURRENT MEDICINE, INC., article "Current Review of Rhinitis", pages: 163 - 173
SCHLEIMER R.P. ET AL.: "glucocorticoids", 2003, MOSBY, INC., article "Middleton's Allergy Principles & Practice Sixth edition", pages: 870 - 913
See also references of EP 1994931A4
AZUMA KOZUE; OHNO SHIGEAKI ET AL.: "Arerugisei Ketsumaku Shikkan Gaisetsu (Outline of allergic conjunctival diseases", 2003, KANEHARA & CO., LTD., article "NEW MOOK Ganka (Ophthalmology); Arerugisei Gan Shikkan (Allergic ophthalmic diseases) 6", pages: 1 - 5
KING H.C. ET AL.: "Pharmacotherapy of allergic rhinitis", 2005, THIEME MEDICAL PUBLISHER, INC., article "Allergy in ENT Practice The basic guide 2nd", pages: 178 - 204
KRAMER M.F. ET AL.: "Nasal IL-16 and MIP-la in late-phase allergic response", ALLERGY AND ASTHMA PROC., vol. 22, 2001, pages 127 - 132
ECONOMIDES A; KALINER M.A.: "Allergic rhinitis", 2002, KALINER M.A. CURRENT MEDICINE, INC., article "Current Review of Rhinitis", pages: 35 - 51
HINGORANI M.; LIGHTMAN S.: "Ocular Allergy", 1997, BLACKWELL SCIENCE, INC., article "Allergy and Allergic Diseases", pages: 1645 - 1670
CIPRANDI G.B ET AL.: "Defrazacort protects against late-phase but early-phase reactions induced by the allergen-specific conjunctival provocation test", ALLERGY, vol. 48, 1993, pages 421 - 430
TAKAMURA ETSUKO, ARERUGISEI KETSUMAKU SHIKKAN NO MENO KAYUMI NO SEIIN TO CHIRYO, vol. 19, 2005, pages 444 - 449
BARNEY N.P.; GRAZIANO F.M. ET AL.: "Allergic and immunological diseases of eye, in Middleton's Allergy principles & practice", 2003, MOSBY, INC., pages: 1599 - 1617
BENSCH G.W. ET AL.: "Evaluation of cytokines in nasal secretions after nasal antigen challenge: lack of influence of antihistamines", ANN. ALLERGY ASTHMA IMMUNOL., vol. 88, 2002, pages 457 - 462
BEREGER W.E. ET AL.: "Efficacy of azelastine nasal spray in patients with an unsatisfactory response to loratadine", ANN. ALLERGY ASTHMA IMMUNOL., vol. 91, 2003, pages 205 - 211
LAFORCE C.F. ET AL.: "Efficacy of azelastine nasal spray in seasonal allergic rhinitis patients who remain symptomatic after treatment with fexofenadine", ANN. ALLERGY ASTHMA IMMUNOL., vol. 93, 2004, pages 154 - 159
DRAIN K.L.; LI J.T.C.: "Corticosteroids and their use in rhinitis", 2002, KALINER M.A. CURRENT MEDICINE, INC., article "Current Review of Rhinitis", pages: 163 - 173
SCHLEIMER R.P. ET AL.: "glucocorticoids", 2003, MOSBY, INC., article "Middleton's Allergy Principles & Practice Sixth edition", pages: 870 - 913
See also references of EP 1994931A4
Attorney, Agent or Firm:
YOSHITAKE, Kenji et al. (Room 323 Fuji Bldg., 2-3, Marunouchi 3-chom, Chiyoda-ku Tokyo 05, JP)
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