Title:
PROPHYLACTIC OR THERAPEUTIC AGENT FOR DIABETES
Document Type and Number:
WIPO Patent Application WO/2013/146911
Kind Code:
A1
Abstract:
The present invention provides: a prophylactic or therapeutic agent for diabetes, which comprises an Nrf2 activator; and a method for screening for a prophylactic or therapeutic agent for diabetes, in which an Nrf2-activating activity is employed as a measure. Thus, a prophylactic or therapeutic agent for diabetes is provided, which has a novel mechanism of action.
Inventors:
YAMAMOTO MASAYUKI (JP)
URUNO AKIRA (JP)
FURUSAWA YUKI (JP)
URUNO AKIRA (JP)
FURUSAWA YUKI (JP)
Application Number:
PCT/JP2013/059069
Publication Date:
October 03, 2013
Filing Date:
March 27, 2013
Export Citation:
Assignee:
MOCHIDA PHARM CO LTD (JP)
UNIV TOHOKU (JP)
UNIV TOHOKU (JP)
International Classes:
A61K45/00; A61K31/56; A61P3/10
Other References:
YI TAN ET AL.: "Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress-Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo", DIABETES, vol. 60, no. 2, 2011, pages 625 - 633
PRADIP K.SAHA ET AL.: "The Triterpenoid 2-Cyano -3,12-dioxooleana -1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet- induced Diabetic Mice and Leprdb/db Mice", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 52, 2010, pages 40581 - 40592
MI-YOUNG SONG ET AL.: "Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-KB pathway", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 235, no. 1, 2009, pages 57 - 67, XP025910485, DOI: doi:10.1016/j.taap.2008.11.007
HONGTING ZHENG ET AL.: "Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy", DIABETES, vol. 60, no. LL, 2011, pages 3055 - 3066
SOONA SHIN ET AL.: "Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 620, no. 1-3, 2009, pages 138 - 144, XP002662970
PRADIP K.SAHA ET AL.: "The Triterpenoid 2-Cyano -3,12-dioxooleana -1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet- induced Diabetic Mice and Leprdb/db Mice", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 52, 2010, pages 40581 - 40592
MI-YOUNG SONG ET AL.: "Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-KB pathway", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 235, no. 1, 2009, pages 57 - 67, XP025910485, DOI: doi:10.1016/j.taap.2008.11.007
HONGTING ZHENG ET AL.: "Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy", DIABETES, vol. 60, no. LL, 2011, pages 3055 - 3066
SOONA SHIN ET AL.: "Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 620, no. 1-3, 2009, pages 138 - 144, XP002662970
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
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