Title:
PROPHYLACTIC OR THERAPEUTIC AGENT FOR FTLD AND METHOD FOR SCREENING SAME
Document Type and Number:
WIPO Patent Application WO/2018/066701
Kind Code:
A1
Abstract:
Provided is a prophylactic or therapeutic agent for frontotemporal lobar degeneration (FTLD), said agent comprising an inhibitor of calcium ion influx into cells. Also provided is a method for screening a prophylactic or therapeutic agent for FTLD, said method comprising: (1) a step for contacting a test substance with cells; (2) a step for measuring calcium ion influx into the cells; (3) a step for comparing the calcium ion influx level measured in (2) with a calcium ion influx level into cells not contacted with the test substance; (4) a step for adding a test substance, which lowers the calcium ion influx level, to neurons having the disease condition of FTLD and detecting or measuring the accumulation or extracellular discharge of misfolded tau proteins; and (5) a step for, when the accumulation or extracellular discharge of misfolded tau proteins is reduced, then selecting the test substance as a candidate for a prophylactic or therapeutic agent for FTLD.
Inventors:
INOUE HARUHISA (JP)
IMAMURA KEIKO (JP)
HIGUCHI MAKOTO (JP)
SAHARA NARUHIKO (JP)
SUHARA TETSUYA (JP)
IMAMURA KEIKO (JP)
HIGUCHI MAKOTO (JP)
SAHARA NARUHIKO (JP)
SUHARA TETSUYA (JP)
Application Number:
PCT/JP2017/036520
Publication Date:
April 12, 2018
Filing Date:
October 06, 2017
Export Citation:
Assignee:
UNIV KYOTO (JP)
NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECH (JP)
NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECH (JP)
International Classes:
A61K45/00; A61P25/00; C12N5/0793; C12N5/10; C12Q1/02; G01N33/15; G01N33/50
Domestic Patent References:
| WO2016076435A1 | 2016-05-19 |
Other References:
COLLEEN M. ET AL.: "Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease", THE ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, vol. 50, 2010, pages 295 - 322, XP002686775, ISSN: 0362-1642
ALEXANDER G M. ET AL.: "Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors", NEURON, vol. 63, 2009, pages 27 - 39, XP055185944, ISSN: 0896-6273
ALEXANDER G M. ET AL.: "Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors", NEURON, vol. 63, 2009, pages 27 - 39, XP055185944, ISSN: 0896-6273
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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