Title:
PROPHYLACTIC OR THERAPEUTIC AGENT FOR HYPERTENSION
Document Type and Number:
WIPO Patent Application WO/2010/092811
Kind Code:
A1
Abstract:
Disclosed is a prophylactic or therapeutic agent for hypertension, which comprises a biphenylcarboxamide compound represented by formula (1) [wherein R1 represents a hydrogen atom or a lower alkoxy group; R2 represents a hydrogen atom or a lower alkanoyl group; and n represents a number of 2 to 5] as an active ingredient.
Inventors:
ISHIGE KUMIKO (JP)
ITO YOSHIHISA (JP)
KOSUGE YASUHIRO (JP)
SUGURE ATSUSHI (JP)
ITO YOSHIHISA (JP)
KOSUGE YASUHIRO (JP)
SUGURE ATSUSHI (JP)
Application Number:
PCT/JP2010/000830
Publication Date:
August 19, 2010
Filing Date:
February 10, 2010
Export Citation:
Assignee:
UNIV NIHON (JP)
ISHIGE KUMIKO (JP)
ITO YOSHIHISA (JP)
KOSUGE YASUHIRO (JP)
SUGURE ATSUSHI (JP)
ISHIGE KUMIKO (JP)
ITO YOSHIHISA (JP)
KOSUGE YASUHIRO (JP)
SUGURE ATSUSHI (JP)
International Classes:
A61K31/495; A61P9/12; C07D295/12
Domestic Patent References:
| WO2007148208A2 | 2007-12-27 |
Foreign References:
| JP2003513053A | 2003-04-08 |
Other References:
TADORI, Y. ET AL.: "Characterization of aripiprazole partial agonist activity at human dopamine D3 receptors", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 597, no. 1-3, 2008, pages 27 - 33
MURRAY, P.J. ET AL.: "A Novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 3, 1995, pages 219 - 222
BOECKLER, F. ET AL.: "Dopamine D3 receptor ligands - Recent advances in the control of subtype selectivity and intrinsic activity", BIOCHIMICA ET BIOPHYSICA ACTA - BIOMEMBRANES, vol. 1768, no. 4, 2007, pages 871 - 887
ZENG, C. ET AL.: "D3 dopamine receptor and essential hypertension", CURRENT HYPERTENSION REVIEWS, vol. 2, no. 3, 2006, pages 247 - 253
ASICO, L.D. ET AL.: "Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension", JOURNAL OF CLINICAL INVESTIGATION, vol. 102, no. 3, 1998, pages 493 - 498
MUHLBAUER, B. ET AL.: "Dopamine D3 receptors in the rat kidney: role in physiology and pathophysiology", ACTA PHYSIOLOGICA SCANDINAVICA, vol. 168, no. 1, 2000, pages 219 - 223
MURRAY, P.J. ET AL.: "A Novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 3, 1995, pages 219 - 222
BOECKLER, F. ET AL.: "Dopamine D3 receptor ligands - Recent advances in the control of subtype selectivity and intrinsic activity", BIOCHIMICA ET BIOPHYSICA ACTA - BIOMEMBRANES, vol. 1768, no. 4, 2007, pages 871 - 887
ZENG, C. ET AL.: "D3 dopamine receptor and essential hypertension", CURRENT HYPERTENSION REVIEWS, vol. 2, no. 3, 2006, pages 247 - 253
ASICO, L.D. ET AL.: "Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension", JOURNAL OF CLINICAL INVESTIGATION, vol. 102, no. 3, 1998, pages 493 - 498
MUHLBAUER, B. ET AL.: "Dopamine D3 receptors in the rat kidney: role in physiology and pathophysiology", ACTA PHYSIOLOGICA SCANDINAVICA, vol. 168, no. 1, 2000, pages 219 - 223
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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