Title:
PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR NASH
Document Type and Number:
WIPO Patent Application WO/2022/260162
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a means that is useful for research and development of the NASH mechanism and a therapeutic method. Also, the present invention addresses the problem of providing a prophylactic and/or therapeutic agent for NASH. To solve these problems, provided is a prophylactic and/or therapeutic agent for NASH that contains a nucleic acid having a specific base sequence. Also provided is a miR-33b knock-in rodent animal fed with a high-fat diet.
Inventors:
ONO KOH (JP)
HORIE TAKAHIRO (JP)
NISHINO TOMOHIRO (JP)
MIYAGAWA SAWA (JP)
OBIKA SATOSHI (JP)
KASAHARA YUYA (JP)
HORIE TAKAHIRO (JP)
NISHINO TOMOHIRO (JP)
MIYAGAWA SAWA (JP)
OBIKA SATOSHI (JP)
KASAHARA YUYA (JP)
Application Number:
PCT/JP2022/023447
Publication Date:
December 15, 2022
Filing Date:
June 10, 2022
Export Citation:
Assignee:
UNIV KYOTO (JP)
UNIV OSAKA (JP)
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
UNIV OSAKA (JP)
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
International Classes:
A61K31/7088; A01K67/027; A23K20/158; A23K50/50; A61K31/7105; A61K48/00; A61P1/16; A61P29/00; A61P43/00; C12N15/113; G01N33/15
Domestic Patent References:
| WO2019245060A1 | 2019-12-26 | |||
| WO2021177267A1 | 2021-09-10 |
Foreign References:
| JP2009532392A | 2009-09-10 | |||
| CN110665010A | 2020-01-10 |
Other References:
SATOSHI KOYAMA, TAKAHIRO HORIE, TOMOHIRO NISHINO, OSAMU BABA, NAOYA SOWA, YUI MIYASAKA, YASUHIDE KUWABARA, TETSUSHI NAKAO, MASATAK: "Iddentification of Differential Roles of MicroRNA-33a and -33b During Atherosclerosis Progression With Genetically Modified Mice", JOURNAL OF THE AMERICAN HEART ASSOCIATION, JOHN WILEY & SONS, vol. 8, no. 13, 27 June 2019 (2019-06-27), pages e012609 - 0012609-26, XP009541848, ISSN: 2047-9980, DOI: 10.1161/JAHA.119.012609
WATARU ONO: "Development of NAFLD and NASH therapy by regulation of microRNA-33a/b involved in cholesterol metabolism", AMED RESEARCH PROJECT INFORMATION "RESEARCH ABSTRACT (2017)", JP, no. 19fk0210028h0003, JP, pages 1 - 2, XP009542853, Retrieved from the Internet
HORIE TAKAHIRO, NISHINO TOMOHIRO, BABA OSAMU, KUWABARA YASUHIDE, NAKAO TETSUSHI, NISHIGA MASATAKA, USAMI SHUNSUKE, IZUHARA MASAYAS: "MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 4, no. 5312, 1 January 2014 (2014-01-01), US , pages 5312 - 5312, XP009541849, ISSN: 2045-2322, DOI: 10.1038/srep05312
MUSSO GIOVANNI, GAMBINO ROBERTO, CASSADER MAURIZIO: "Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis", PROGRESS IN LIPID RESEARCH., PERGAMON PRESS, PARIS., FR, vol. 52, no. 1, 1 January 2013 (2013-01-01), FR , pages 175 - 191, XP009541850, ISSN: 0163-7827, DOI: 10.1016/j.plipres.2012.11.002
AUGUET TERESA, ARAGONÈS GEMMA, BERLANGA ALBA, GUIU-JURADO ESTHER, MARTÍ ANDREU, MARTÍNEZ SALOMÉ, SABENCH FÀTIMA, HERNÁNDEZ MERCÉ, : "miR33a/miR33b* and miR122 as Possible Contributors to Hepatic Lipid Metabolism in Obese Women with Nonalcoholic Fatty Liver Disease", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 17, no. 10, 1 October 2016 (2016-10-01), Basel, CH , pages 1620, XP009541851, ISSN: 1422-0067, DOI: 10.3390/ijms17101620
WATARU ONO AND OTHERS: "S5-1: Discovery of a novel drug for non-alcoholic fatty liver disease (NASH)", PROGRAM OF THE 53RD ANNUAL MEETING OF THE JAPAN ATHEROSCLEROSIS SOCIETY, JAPAN ATHEROSCLEROSIS SOCIETY, JP, vol. 53, 1 January 2021 (2021-01-01) - 24 October 2021 (2021-10-24), JP, pages 105, XP009541852
WATARU ONO: "Development of NAFLD and NASH therapy by regulation of microRNA-33a/b involved in cholesterol metabolism", AMED RESEARCH PROJECT INFORMATION "RESEARCH ABSTRACT (2017)", JP, no. 19fk0210028h0003, JP, pages 1 - 2, XP009542853, Retrieved from the Internet
HORIE TAKAHIRO, NISHINO TOMOHIRO, BABA OSAMU, KUWABARA YASUHIDE, NAKAO TETSUSHI, NISHIGA MASATAKA, USAMI SHUNSUKE, IZUHARA MASAYAS: "MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 4, no. 5312, 1 January 2014 (2014-01-01), US , pages 5312 - 5312, XP009541849, ISSN: 2045-2322, DOI: 10.1038/srep05312
MUSSO GIOVANNI, GAMBINO ROBERTO, CASSADER MAURIZIO: "Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis", PROGRESS IN LIPID RESEARCH., PERGAMON PRESS, PARIS., FR, vol. 52, no. 1, 1 January 2013 (2013-01-01), FR , pages 175 - 191, XP009541850, ISSN: 0163-7827, DOI: 10.1016/j.plipres.2012.11.002
AUGUET TERESA, ARAGONÈS GEMMA, BERLANGA ALBA, GUIU-JURADO ESTHER, MARTÍ ANDREU, MARTÍNEZ SALOMÉ, SABENCH FÀTIMA, HERNÁNDEZ MERCÉ, : "miR33a/miR33b* and miR122 as Possible Contributors to Hepatic Lipid Metabolism in Obese Women with Nonalcoholic Fatty Liver Disease", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL (MDPI), BASEL, CH, vol. 17, no. 10, 1 October 2016 (2016-10-01), Basel, CH , pages 1620, XP009541851, ISSN: 1422-0067, DOI: 10.3390/ijms17101620
WATARU ONO AND OTHERS: "S5-1: Discovery of a novel drug for non-alcoholic fatty liver disease (NASH)", PROGRAM OF THE 53RD ANNUAL MEETING OF THE JAPAN ATHEROSCLEROSIS SOCIETY, JAPAN ATHEROSCLEROSIS SOCIETY, JP, vol. 53, 1 January 2021 (2021-01-01) - 24 October 2021 (2021-10-24), JP, pages 105, XP009541852
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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