Title:
PROPHYLACTIC OR THERAPEUTIC AGENT FOR ORGAN FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2018/003997
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a safe and easy-to-prepare cell preparation for prevention and/or treatment of organ fibrosis such as liver fibrosis. Provided is a cell preparation for prevention and/or treatment of organ fibrosis such as liver fibrosis, the cell preparation including a SSEA-3-positive pluripotent stem cell (Muse cell) derived from a vital mesenchymal tissue or a cultured mesenchymal cell.
Inventors:
DEZAWA MARI (JP)
UNNO MICHIAKI (JP)
YAMAMOTO TOSHIHIRO (JP)
SHINDO YASUHIRO (JP)
HARA HIROTO (JP)
MASUTOMI NAOYA (JP)
UNNO MICHIAKI (JP)
YAMAMOTO TOSHIHIRO (JP)
SHINDO YASUHIRO (JP)
HARA HIROTO (JP)
MASUTOMI NAOYA (JP)
Application Number:
PCT/JP2017/024246
Publication Date:
January 04, 2018
Filing Date:
June 30, 2017
Export Citation:
Assignee:
UNIV TOHOKU (JP)
LIFE SCIENCE INST INC (JP)
LIFE SCIENCE INST INC (JP)
International Classes:
A61K35/545; A61P1/00; A61P1/16; A61P5/00; A61P9/00; A61P11/00; A61P13/00; A61P15/00; A61P17/00; A61P25/00
Domestic Patent References:
| WO2014027684A1 | 2014-02-20 | |||
| WO2008140141A1 | 2008-11-20 | |||
| WO2014089397A1 | 2014-06-12 | |||
| WO2016054155A1 | 2016-04-07 |
Other References:
SHUICHI KANEKO: "C-gata Kan'en kara Hatsugan ni Itaru Byotai Shinten no Kaimei to sono Seigyo ni Kansuru Kenkyu", KOSEI RODO KAGAKU KENKYUHI HOJOKIN KAN'EN TO KOKUFUKU JITSUYOKA KENKYU JIGYO, HEISEI 26 NENDO SOKATSU · BUNTAN KENKYU HOKOKUSHO, 2015, pages 1 - 11, XP009518761
ZHAO, W. ET AL.: "Intravenous injection of mesenchymal stem cells is effective in treating liver fibrosis", WORLD J. GASTROENTEROLOGY, vol. 18, no. 10, 2012, pages 1048 - 1058, XP055452379
NORIYUKI KATSUNO ET AL.: "Treatment of refractory kidney diseases using adipose tissue-derived stromal cells", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 242, no. 4, 2012, pages 289 - 295, XP009514178, ISSN: 0039-2359
LI, W. ET AL.: "Isogenic mesenchymal stem cells transplantation improves a rat model of chronic aristolochic acid nephropathy via upregulation of hepatic growth factor and downregulation of transforming growth factor beta1", MOL. CELL . BIOCHEM., vol. 368, no. 1-2, 4 June 2012 (2012-06-04), pages 137 - 145, XP035091077
ISEKI, M. ET AL.: "Human Muse Cells, Nontumorigenic Pluripotent-Like Stem Cells, Have Liver Regeneration Capacity Through Specific Homing and Cell Replacement in a Mouse Model of Liver Fibrosis", CELL TRANSPLANTATION, vol. 26, no. 5, 1 May 2017 (2017-05-01), pages 821 - 840, XP055453778, ISSN: 0963-6897, DOI: 10.3727/096368916X693662
MARI DEZAWA: "Muse Saibo ga Motarasu Iryo Kakushin", DAI 14 KAI JAPAN RESEARCH ASSOCIATION FOR IMMUNOTHERAPEUTICS GAKUJUTSU SHUKAI PROGRAM ·SHOROKUSHU; 14TH ANNUAL MEETING OF JAPAN RESEARCH ASSOCIATION OF IMMUNOTHERAPISTS; 11/02/2017, 27 January 2017 (2017-01-27), JAPAN, pages 14 - 15, XP009518615
ZHAO, W. ET AL.: "Intravenous injection of mesenchymal stem cells is effective in treating liver fibrosis", WORLD J. GASTROENTEROLOGY, vol. 18, no. 10, 2012, pages 1048 - 1058, XP055452379
NORIYUKI KATSUNO ET AL.: "Treatment of refractory kidney diseases using adipose tissue-derived stromal cells", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 242, no. 4, 2012, pages 289 - 295, XP009514178, ISSN: 0039-2359
LI, W. ET AL.: "Isogenic mesenchymal stem cells transplantation improves a rat model of chronic aristolochic acid nephropathy via upregulation of hepatic growth factor and downregulation of transforming growth factor beta1", MOL. CELL . BIOCHEM., vol. 368, no. 1-2, 4 June 2012 (2012-06-04), pages 137 - 145, XP035091077
ISEKI, M. ET AL.: "Human Muse Cells, Nontumorigenic Pluripotent-Like Stem Cells, Have Liver Regeneration Capacity Through Specific Homing and Cell Replacement in a Mouse Model of Liver Fibrosis", CELL TRANSPLANTATION, vol. 26, no. 5, 1 May 2017 (2017-05-01), pages 821 - 840, XP055453778, ISSN: 0963-6897, DOI: 10.3727/096368916X693662
MARI DEZAWA: "Muse Saibo ga Motarasu Iryo Kakushin", DAI 14 KAI JAPAN RESEARCH ASSOCIATION FOR IMMUNOTHERAPEUTICS GAKUJUTSU SHUKAI PROGRAM ·SHOROKUSHU; 14TH ANNUAL MEETING OF JAPAN RESEARCH ASSOCIATION OF IMMUNOTHERAPISTS; 11/02/2017, 27 January 2017 (2017-01-27), JAPAN, pages 14 - 15, XP009518615
Attorney, Agent or Firm:
SANUKI, Shinichi et al. (JP)
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