Title:
PROPHYLACTIC OR THERAPEUTIC AGENT FOR RESPIRATORY DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/054578
Kind Code:
A1
Abstract:
The present invention pertains to a pharmaceutical composition for the prevention or treatment of respiratory diseases, particularly, inflammatory respiratory diseases, the pharmaceutical composition containing, as an active ingredient, a compound having a P2X4 receptor antagonizing effect or a pharmaceutically acceptable salt of said compound.
Inventors:
IMAI TOSHIYASU (JP)
Application Number:
PCT/JP2022/036415
Publication Date:
April 06, 2023
Filing Date:
September 29, 2022
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO (JP)
International Classes:
A61K45/00; A61K31/5513; A61P11/00; A61P29/00
Domestic Patent References:
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Foreign References:
| JP2021162383A | 2021-10-11 |
Other References:
ZECH ANDREAS, WIESLER BENJAMIN, AYATA CEMIL KORCAN, SCHLAICH TILMANN, DÜRK THORSTEN, HOSSFELD MADELON, EHRAT NICOLAS, CICKO SANJA,: "P2rx4 deficiency in mice alleviates allergen-induced airway inflammation", ONCOTARGET, vol. 7, no. 49, 6 December 2016 (2016-12-06), pages 80288 - 80297, XP093052756, DOI: 10.18632/oncotarget.13375
SCHNEIDER SVEN, SANJA CICKO, ANDREAS ZECH, MADELON HOSSFELD, MARCO IDZKO: "P2RX4 signalling enhances acute cigarette smoke-induced lung inflammation and chronic lung emphysema development ", EUROPEAN RESPIRATORY JOURNAL, 1 January 2019 (2019-01-01), XP093052760, Retrieved from the Internet [retrieved on 20230608], DOI: 10.1183/13993003.congress-2019.PA4218
OBARA KEISUKE, RIKAKO INABA, MIRAI KAWAKITA, AZUSA MURATA, KENTO YOSHIOKA, YOSHIO TANAKA: "Effects of NP-1815-PX, a P2X4 Receptor Antagonist, on Contractions in Guinea Pig Tracheal and Bronchial Smooth Muscles", BIOL PHARM BULL, vol. 45, no. 8, 1 January 2022 (2022-01-01), pages 1158 - 1165, XP093052769, DOI: 10.1248/bpb.b22-00234
SCHNEIDER SVEN, MERFORT IRMGARD, IDZKO MARCO, ZECH ANDREAS: "Blocking P2X purinoceptor 4 signalling alleviates cigarette smoke induced pulmonary inflammation", RESPIRATORY RESEARCH, vol. 23, no. 1, 1 December 2022 (2022-12-01), XP093052772, DOI: 10.1186/s12931-022-02072-z
JUN-ICHI FUCHIKAMIMAKI TAKAHASHI: "Cigarette smoke-induced animal models to evaluate drug efficacy on chronic obstructive pulmonary disease (COPD", FOLIA PHARMACOL. JPN., vol. 127, 2006, pages 183 - 189
NICOLE M. R. ET AL.: "An update and systematic review on drug therapies for the treatment of refractory chronic cough", EXPERT OPINION PHARMACOTHERAPY, vol. 19, no. 7, May 2018 (2018-05-01), pages 687 - 711
SCHNEIDER SVEN, SANJA CICKO, ANDREAS ZECH, MADELON HOSSFELD, MARCO IDZKO: "P2RX4 signalling enhances acute cigarette smoke-induced lung inflammation and chronic lung emphysema development ", EUROPEAN RESPIRATORY JOURNAL, 1 January 2019 (2019-01-01), XP093052760, Retrieved from the Internet
OBARA KEISUKE, RIKAKO INABA, MIRAI KAWAKITA, AZUSA MURATA, KENTO YOSHIOKA, YOSHIO TANAKA: "Effects of NP-1815-PX, a P2X4 Receptor Antagonist, on Contractions in Guinea Pig Tracheal and Bronchial Smooth Muscles", BIOL PHARM BULL, vol. 45, no. 8, 1 January 2022 (2022-01-01), pages 1158 - 1165, XP093052769, DOI: 10.1248/bpb.b22-00234
SCHNEIDER SVEN, MERFORT IRMGARD, IDZKO MARCO, ZECH ANDREAS: "Blocking P2X purinoceptor 4 signalling alleviates cigarette smoke induced pulmonary inflammation", RESPIRATORY RESEARCH, vol. 23, no. 1, 1 December 2022 (2022-12-01), XP093052772, DOI: 10.1186/s12931-022-02072-z
JUN-ICHI FUCHIKAMIMAKI TAKAHASHI: "Cigarette smoke-induced animal models to evaluate drug efficacy on chronic obstructive pulmonary disease (COPD", FOLIA PHARMACOL. JPN., vol. 127, 2006, pages 183 - 189
NICOLE M. R. ET AL.: "An update and systematic review on drug therapies for the treatment of refractory chronic cough", EXPERT OPINION PHARMACOTHERAPY, vol. 19, no. 7, May 2018 (2018-05-01), pages 687 - 711
Attorney, Agent or Firm:
TAZAKI Akira et al. (JP)
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