PROPYLENE GLYCOL-CONTAINING PEPTIDE FORMULATIONS WHICH ARE OPTIMAL FOR PRODUCTION AND FOR USE IN INJECTION DEVICES

WIPO Patent Application WO2005049061

A3

The present invention relates to pharmaceutical formulations comprising a peptide and propylene glycol, to methods of preparing such formulations, and to uses of such formu-lations in the treatment of diseases and conditions for which use of the peptide contained in such formulations is indicated. The present invention further relates to methods for reducing the clogging of injection devices by a peptide formulation and for reducing deposits on pro-duction equipment during production of a peptide formulation.

PEDERSEN TINA BJELDSKOV (DK)
BONDE CLAUDE (DK)
ENGELUND DORTHE KOT (DK)

PCT/DK2004/000792

October 20, 2005

November 18, 2004

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NOVO NORDISK AS (DK)
PEDERSEN TINA BJELDSKOV (DK)
BONDE CLAUDE (DK)
ENGELUND DORTHE KOT (DK)

A61K38/26; A61K38/28; A61K47/10; A61K47/18; A61K47/20; A61K47/26; (IPC1-7): A61K38/26; A61K38/27; A61K38/28

WO2005046716A1	2005-05-26
WO1993023010A1	1993-11-25
WO1995013825A1	1995-05-26
WO1999016417A1	1999-04-08
WO2003013589A1	2003-02-20
WO1995022560A1	1995-08-24
WO1995005848A1	1995-03-02
WO2002067989A1	2002-09-06
WO1992019260A1	1992-11-12

US20020151467A1	2002-10-17
US5206219A	1993-04-27

SINGH, SOMNATH ET AL: "Effect of polyols on the conformational stability and biological activity of a model protein lysozyme", AAPS PHARMSCITECH , 4(3), 334-342 CODEN: AAPHFZ; ISSN: 1522-1059 URL: HTTP://WWW.AAPSPHARMSCITECH.ORG/PT0403/PT040342/PT040342.PDF, October 2003 (2003-10-01), XP002342618

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