Title:
PROSTAGLANDIN ANALOGS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/091358
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for the prevention or treatment of a disease, disorder, or condition associated with Nurr1, including, as an active ingredient, a prostaglandin analog or a pharmaceutically acceptable salt thereof, wherein the compound has excellent effects in inducing Nurr1, and thus, can be useful as a pharmaceutical composition for the prevention or treatment of a disease, disorder, or condition associated with Nurr1, in particular, cancer, autoimmune disease such as rheumatoid arthiritis, schizophrenia, manic depression and neurodegenerative disease such as Alzheimers disease or Parkinson's disease.
Inventors:
YOON CHEOLHWAN (KR)
KANG HONGJUN (KR)
HAN CHEOLKYU (KR)
KIM MOONHWAN (KR)
SEO JEONGBEOB (KR)
YOO JUN YEOB (SG)
RAJAN SREEKANTH (SG)
YOON HO SUP (SG)
KANG HONGJUN (KR)
HAN CHEOLKYU (KR)
KIM MOONHWAN (KR)
SEO JEONGBEOB (KR)
YOO JUN YEOB (SG)
RAJAN SREEKANTH (SG)
YOON HO SUP (SG)
Application Number:
PCT/KR2020/015655
Publication Date:
May 14, 2021
Filing Date:
November 09, 2020
Export Citation:
Assignee:
LIFEX BIOLABS INC (US)
YOO OOK JOON (KR)
YOO OOK JOON (KR)
International Classes:
C07C405/00; A61K31/5575; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P35/00; A61P37/00
Domestic Patent References:
WO2004035083A2 | 2004-04-29 | |||
WO2019023579A1 | 2019-01-31 |
Foreign References:
US4012427A | 1977-03-15 | |||
US20100074857A1 | 2010-03-25 |
Other References:
HOLLA VIJAYKUMAR R., JASON R. MANN, QIONG SHI, RAYMOND N. DUBOIS: "Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, no. 5, 1 January 2006 (2006-01-01), pages 2676 - 2682, XP055810314, DOI: 10.1074/jbc.M507752200
See also references of EP 4055007A4
See also references of EP 4055007A4
Attorney, Agent or Firm:
YOU ME PATENT AND LAW FIRM (KR)
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