PROSTAGLANDIN DERIVATIVE

WIPO Patent Application WO/2006/137472

A1

A prostaglandin derivative represented by the formula: (I) wherein R¹ represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or an alkenyl group having 2 to 4 carbon atoms; X represents an ethylene group, a trimethylene group, a vinylene group, an ethynylene group or a group represented by the formula: -SCH₂-; R² and R³ independently represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, a haloalkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an alkyl group having 1 to 6 carbon atoms which is substituted by an alkoxy group having 1 to 6 carbon atoms, a phenyl group, a substituted phenyl group, a furyl group or a thienyl group, or a pharmaceutically acceptable salt thereof or a hydrate of the derivative or salt. These compounds show a satisfactory level of anti-inflammatory effect while minimizing the cAMP production-enhancing effect and is provided for reducing the adverse side effects that may be caused by an EP4 agonist.

ONO NAOYA (JP)
YAGI MAKOTO (JP)
KAWAMURA MADOKA (JP)
CHONAN TOMOMICHI (JP)
TANAMI TOHRU (JP)
TAKAHASHI HITOMI (JP)
TANAKA HIDEO (JP)

PCT/JP2006/312484

December 28, 2006

June 22, 2006

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TAISHO PHARMACEUTICAL CO LTD (JP)
ONO NAOYA (JP)
YAGI MAKOTO (JP)
KAWAMURA MADOKA (JP)
CHONAN TOMOMICHI (JP)
TANAMI TOHRU (JP)
TAKAHASHI HITOMI (JP)
TANAKA HIDEO (JP)

C07C405/00; A61P29/00; A61K31/5575

WO2001017957A1

2001-03-15

JPS5484555A

1979-07-05

Satori, Soichi c/o Taisho Pharmaceutical Co. Ltd. (Intellectual Property Division, 24-1, Takada 3-chome, Toshima-k, Tokyo 33, JP)

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