Title:
PROTECTIVE AGENT FOR RETINA NEURONS
Document Type and Number:
WIPO Patent Application WO/2022/249942
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a protective agent for neurons of the retina exemplified by retinal ganglion cells and retinal photoreceptor cells. As a means for solving the problem, this protective agent for neurons of the retina has, as an active ingredient, a compound represented by the general formula R1-(CH2)m-S R2 or a pharmaceutically acceptable salt thereof.
In the formula, R1 indicates -NR3R4 or an alkyl group with a carbon number of 1-6. R2 indicates a hydrogen atom or -S-(CH2)n-N R5R6. R3 to R6 are the same or different and each represent a hydrogen atom or an acetyl group. m and n are the same or different and each indicate an integer from 2 to 4.
Inventors:
YAMASHITA TETSURO (JP)
OZAKI TAKU (JP)
OZAKI TAKU (JP)
Application Number:
PCT/JP2022/020635
Publication Date:
December 01, 2022
Filing Date:
May 18, 2022
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION IWATE UNIV (JP)
International Classes:
A61K31/131; A61K31/145; A61P25/00; A61P27/02; A61P27/06
Domestic Patent References:
| WO2008122032A2 | 2008-10-09 |
Foreign References:
| JP2016540827A | 2016-12-28 |
Other References:
D'ONOFRIO PHILIPPE M., SHABANZADEH ALIREZA P., CHOI BRIAN K., BÄHR MATHIAS, KOEBERLE PAULO D.: "MMP Inhibition Preserves Integrin Ligation and FAK Activation to Induce Survival and Regeneration in RGCs Following Optic Nerve Damage", INVESTIGATIVE OPTHALMOLOGY & VISUAL SCIENCE, ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY, US, vol. 60, no. 2, 1 February 2019 (2019-02-01), US , pages 634 - 649, XP093007467, ISSN: 1552-5783, DOI: 10.1167/iovs.18-25257
MING-HUI SUN, KUAN-JEN CHEN, YEOU-PING TSAO, LING-YUH KAO, WEN-HWA HAN, KEN-KUO LIN, JONG-HWEI SU PANG: "Down-Regulation of Matrix Metalloproteinase-9 by Pyrrolidine Dithiocarbamate Prevented Retinal Ganglion Cell Death After Transection of Optic Nerve in Rats", CURRENT EYE RESEARCH, INFORMA HEALTHCARE USA, US, vol. 36, no. 11, 1 November 2011 (2011-11-01), US , pages 1053 - 1063, XP009541255, ISSN: 0271-3683, DOI: 10.3109/02713683.2011.606591
PAUL BINDU D., SNYDER SOLOMON H.: "Therapeutic Applications of Cysteamine and Cystamine in Neurodegenerative and Neuropsychiatric Diseases", FRONTIERS IN NEUROLOGY, vol. 10, 1 December 2019 (2019-12-01), pages 1315 - 9, XP093007473, ISSN: 1664-2295, DOI: 10.3389/fneur.2019.01315
PAMELA MAHER, JAN LEWERENZ, CARLES LOZANO, JOSEP LLUÍS TORRES: "A novel approach to enhancing cellular glutathione levels", JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 107, no. 3, 1 November 2008 (2008-11-01), GB , pages 690 - 700, XP055368450, ISSN: 0022-3042, DOI: 10.1111/j.1471-4159.2008.05620.x
KUROSE TAKAHIRO, KUROSE TAKAHIRO, SUGANO ERIKO, SUGAI AKIHISA, SHIRAIWA RAKI, KATO MARIYO, MITSUGUCHI YOKO, TAKAI YOSHIHIRO, TABAT: "Neuroprotective effect of a dietary supplement against glutamate-induced excitotoxicity in retina", INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, INTERNATIONAL COUNCIL OF OPHTHALMOLOGY, CN, vol. 12, no. 8, 18 August 2019 (2019-08-18), CN , pages 1231 - 1237, XP093007474, ISSN: 2222-3959, DOI: 10.18240/ijo.2019.08.01
MING-HUI SUN, KUAN-JEN CHEN, YEOU-PING TSAO, LING-YUH KAO, WEN-HWA HAN, KEN-KUO LIN, JONG-HWEI SU PANG: "Down-Regulation of Matrix Metalloproteinase-9 by Pyrrolidine Dithiocarbamate Prevented Retinal Ganglion Cell Death After Transection of Optic Nerve in Rats", CURRENT EYE RESEARCH, INFORMA HEALTHCARE USA, US, vol. 36, no. 11, 1 November 2011 (2011-11-01), US , pages 1053 - 1063, XP009541255, ISSN: 0271-3683, DOI: 10.3109/02713683.2011.606591
PAUL BINDU D., SNYDER SOLOMON H.: "Therapeutic Applications of Cysteamine and Cystamine in Neurodegenerative and Neuropsychiatric Diseases", FRONTIERS IN NEUROLOGY, vol. 10, 1 December 2019 (2019-12-01), pages 1315 - 9, XP093007473, ISSN: 1664-2295, DOI: 10.3389/fneur.2019.01315
PAMELA MAHER, JAN LEWERENZ, CARLES LOZANO, JOSEP LLUÍS TORRES: "A novel approach to enhancing cellular glutathione levels", JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 107, no. 3, 1 November 2008 (2008-11-01), GB , pages 690 - 700, XP055368450, ISSN: 0022-3042, DOI: 10.1111/j.1471-4159.2008.05620.x
KUROSE TAKAHIRO, KUROSE TAKAHIRO, SUGANO ERIKO, SUGAI AKIHISA, SHIRAIWA RAKI, KATO MARIYO, MITSUGUCHI YOKO, TAKAI YOSHIHIRO, TABAT: "Neuroprotective effect of a dietary supplement against glutamate-induced excitotoxicity in retina", INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, INTERNATIONAL COUNCIL OF OPHTHALMOLOGY, CN, vol. 12, no. 8, 18 August 2019 (2019-08-18), CN , pages 1231 - 1237, XP093007474, ISSN: 2222-3959, DOI: 10.18240/ijo.2019.08.01
Attorney, Agent or Firm:
TSUJITA Takashi (JP)
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