Title:
PROTEIN-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF COLORECTAL ADENOCARCINOMA
Document Type and Number:
WIPO Patent Application WO/2010/119362
Kind Code:
A8
Abstract:
Protein-based methods and compositions for the diagnosis of colorectal adenocarcinoma are disclosed. A method for identifying cell-surface proteins, which are transmembrane proteins or proteins with a signal peptide and which are over-expressed in colorectal cancer (CRC) is disclosed. Biomarkers found with this method, diagnostic methods using them and contrast agents directed to them for use in magnetic resonance imaging (MRI) and /or magentic photon imaging (MPI) are disclosed. The methods and biomarkers allow for differentiating progressive (high-risk) CRC (adenocarcinomas) from non-progressive (low-risk) colorectal adenomas.
Inventors:
DE WIT MEIKE (NL)
FIJNEMAN REMONDUS J A (NL)
JIMENEZ CORNELIA R (NL)
MEIJER GERRIT A (NL)
FIJNEMAN REMONDUS J A (NL)
JIMENEZ CORNELIA R (NL)
MEIJER GERRIT A (NL)
Application Number:
PCT/IB2010/051395
Publication Date:
November 10, 2011
Filing Date:
March 31, 2010
Export Citation:
Assignee:
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL)
DE WIT MEIKE (NL)
FIJNEMAN REMONDUS J A (NL)
JIMENEZ CORNELIA R (NL)
MEIJER GERRIT A (NL)
DE WIT MEIKE (NL)
FIJNEMAN REMONDUS J A (NL)
JIMENEZ CORNELIA R (NL)
MEIJER GERRIT A (NL)
International Classes:
G01N33/574; A61K49/00; C07K14/00
Attorney, Agent or Firm:
KROEZE, John et al. (AE Eindhoven, NL)
Download PDF:
Previous Patent: ADHESIVE ELEMENT FOR ADHESION TESTS AND CORRESPONDING TESTING PROCESS
Next Patent: TUMOR TREATMENT USING ULTRASOUND CAVITATION
Next Patent: TUMOR TREATMENT USING ULTRASOUND CAVITATION