Title:
PROTEIN COMPLEXES INVOLVED IN NEUROLOGICAL DISEASES
Document Type and Number:
WIPO Patent Application WO2004031242
Kind Code:
A3
Abstract:
The present invention relates to protein complexes involved in cellular processes which have been shown to be critical for the development of various forms of neurological diseases, to component proteins of the said complexes, to fragments and derivatives of the component proteins and to antibodies specific to the complexes. It further relates to methods for use of the complexes and their interacting proteins in, inter alia, screening, diagnosis and therapy, as well as to methods of preparing said complexes.
Inventors:
BOUWMEESTER TEWIS (DE)
DREWES GERARD (DE)
JACKSON DAVID (DE)
HELFTENBEIN GERD (DE)
SCHIRLE MARKUS (DE)
KUESTER BERNHARD (DE)
HOPF CARSTEN (DE)
DREWES GERARD (DE)
JACKSON DAVID (DE)
HELFTENBEIN GERD (DE)
SCHIRLE MARKUS (DE)
KUESTER BERNHARD (DE)
HOPF CARSTEN (DE)
Application Number:
PCT/EP2003/010110
Publication Date:
August 05, 2004
Filing Date:
September 11, 2003
Export Citation:
Assignee:
CELLZOME AG (DE)
BOUWMEESTER TEWIS (DE)
DREWES GERARD (DE)
JACKSON DAVID (DE)
HELFTENBEIN GERD (DE)
SCHIRLE MARKUS (DE)
KUESTER BERNHARD (DE)
HOPF CARSTEN (DE)
BOUWMEESTER TEWIS (DE)
DREWES GERARD (DE)
JACKSON DAVID (DE)
HELFTENBEIN GERD (DE)
SCHIRLE MARKUS (DE)
KUESTER BERNHARD (DE)
HOPF CARSTEN (DE)
International Classes:
C07K14/47; C12N15/12; (IPC1-7): C07K14/47; A61K38/17; C07K16/18; C12N9/00; C12N15/12; C12N15/52; C12N15/62; C12Q1/68; G01N33/50
Domestic Patent References:
| WO2001083739A2 | 2001-11-08 | |||
| WO2002064736A2 | 2002-08-22 | |||
| WO2001061001A2 | 2001-08-23 | |||
| WO2002092626A2 | 2002-11-21 |
Other References:
MAMIDIPUDI V WOOTEN M W: "IRAK and the atypical PCK interacting protein p62 are critical components in p75-neurotrophin activation of NF-(kappa) B", FASEB JOURNAL (FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY), BETHESDA, US, vol. 16, no. 5, 2002, pages A1196,ABSTRACTNO8881, XP002956846, ISSN: 0892-6638
CHEN BING-CHANG ET AL: "Inhibition of interleukin-1beta-induced NF-kappaB activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 27, 5 July 2002 (2002-07-05), pages 24169 - 24179, XP002268505, ISSN: 0021-9258
CAO Z ET AL: "IRAK: A KINASE ASSOCIATED WITH THE INERLEUKIN-1 RECEPTOR", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 271, no. 5252, 23 February 1996 (1996-02-23), pages 1128 - 1131, XP001026471, ISSN: 0036-8075
DATABASE EMBL [online] 1 March 2002 (2002-03-01), STRAUSBERG R., XP002268507, accession no. EBI Database accession no. Q8VC03
LI SHYUN ET AL: "IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 99, no. 8, 16 April 2002 (2002-04-16), April 16, 2002, pages 5567 - 5572, XP002268506, ISSN: 0027-8424
WANG X S ET AL: "MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 253, no. 1, 9 December 1998 (1998-12-09), pages 33 - 37, XP002169311, ISSN: 0006-291X
CHEN BING-CHANG ET AL: "Inhibition of interleukin-1beta-induced NF-kappaB activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 27, 5 July 2002 (2002-07-05), pages 24169 - 24179, XP002268505, ISSN: 0021-9258
CAO Z ET AL: "IRAK: A KINASE ASSOCIATED WITH THE INERLEUKIN-1 RECEPTOR", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 271, no. 5252, 23 February 1996 (1996-02-23), pages 1128 - 1131, XP001026471, ISSN: 0036-8075
DATABASE EMBL [online] 1 March 2002 (2002-03-01), STRAUSBERG R., XP002268507, accession no. EBI Database accession no. Q8VC03
LI SHYUN ET AL: "IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 99, no. 8, 16 April 2002 (2002-04-16), April 16, 2002, pages 5567 - 5572, XP002268506, ISSN: 0027-8424
WANG X S ET AL: "MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 253, no. 1, 9 December 1998 (1998-12-09), pages 33 - 37, XP002169311, ISSN: 0006-291X
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