Title:
PROTEIN DERIVED FROM FIBRONECTIN TYPE III DOMAIN, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/092717
Kind Code:
A1
Abstract:
Provided is a protein derived from a fibronectin type III domain, and the use thereof. The protein comprises the 10th human fibronectin type III domain, and comprises a first mutation where one amino acid site is substituted with one cysteine and a second mutation where another amino acid site is substituted with another cysteine. The first mutation and the second mutation occur in regions other than the loop FG of the 10th human fibronectin type III domain, whereby the cysteine after the substitution in the first mutation and the cysteine after the substitution in the second mutation form a disulfide bond.
Inventors:
CHUANG WOEI JER (CN)
Application Number:
PCT/CN2022/129857
Publication Date:
May 10, 2024
Filing Date:
November 04, 2022
Export Citation:
Assignee:
CHUANG WOEI JER (CN)
International Classes:
C07K14/78; A61K38/00
Foreign References:
| US20150368319A1 | 2015-12-24 | |||
| US20130184212A1 | 2013-07-18 | |||
| US20090299040A1 | 2009-12-03 | |||
| CN1946417A | 2007-04-11 | |||
| CN106795214A | 2017-05-31 |
Other References:
PARKER M H ET AL: "Antibody mimics based on human fibronectin type three domain engineered for thermostability and high-affinity binding to vascular endothelial growth factor receptor two.", PROTEIN ENGINEERING, DESIGN AND SELECTION, OXFORD JOURNAL, LONDON, GB, vol. 18, no. 9, 1 September 2005 (2005-09-01), GB , pages 435 - 444, XP002457979, ISSN: 1741-0126, DOI: 10.1093/protein/gzi050
Attorney, Agent or Firm:
SHANGHAI YUANTONG LAW FIRM (CN)
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