Title:
PROTEIN DIAGNOSTIC BIOMARKER FOR SEVERE DRUG ERUPTION
Document Type and Number:
WIPO Patent Application WO/2021/210651
Kind Code:
A1
Abstract:
To develop biomarkers for diagnosis of the pathology, exacerbation, and type of severe drug eruptions such as drug-induced hypersensitivity syndrome and Stevens-Johnson syndrome/toxic epidermal necrolysis. A test method for severe drug eruption that includes measuring the expression of at least one protein selected from the group consisting of stratifin, TNF receptor superfamily member 8 (CD30/TNFRSF8), interleukin-1 receptor antagonist (IL-1Ra), and TNF receptor superfamily member 6B (DcR3/TNFRSF6B) in a sample derived from a subject.
Inventors:
SAITO YOSHIRO (JP)
NAKAMURA RYOSUKE (JP)
ARAKAWA NORIAKI (JP)
OHNO YASUO (JP)
IZUMI TAKASHI (JP)
SATO MOTONOBU (JP)
NISHIYA TAKAYOSHI (JP)
AIHARA MICHIKO (JP)
NAKAMURA RYOSUKE (JP)
ARAKAWA NORIAKI (JP)
OHNO YASUO (JP)
IZUMI TAKASHI (JP)
SATO MOTONOBU (JP)
NISHIYA TAKAYOSHI (JP)
AIHARA MICHIKO (JP)
Application Number:
PCT/JP2021/015613
Publication Date:
October 21, 2021
Filing Date:
April 15, 2021
Export Citation:
Assignee:
JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NAT INSTITUTE OF HEALTH SCIENCES (JP)
International Classes:
C12Q1/6837; C12Q1/6876; G01N33/68
Domestic Patent References:
| WO2019202972A1 | 2019-10-24 |
Foreign References:
| JP2010286375A | 2010-12-24 | |||
| JP2012039970A | 2012-03-01 | |||
| JP2020073955A | 2020-05-14 |
Other References:
AIHARA, MICHIKO : "Evaluation of serum cytokine levels in toxic epidermal necrolysis and Stevens-Johnson syndrome compared with other delayed-type adverse drug reactions", THE JOURNAL OF DERMATOLOGY, vol. 38, no. 11, 2011, pages 1076 - 1079, XP009531088, ISSN: 0385-2407, DOI: 10.1111/j.1346-8138.2010.01170.x
HAMA NATSUMI, NISHIMURA KEIKO, HASEGAWA AKITO, YUKI AKIHIKO, KUME HIDEAKI, ADACHI JUN, KINOSHITA MANAO, OGAWA YOUICHI, NAKAJIMA SA: "Galectin-7 as a potential biomarker of Stevens-Johnson syndrome/toxic epidermal necrolysis: identification by targeted proteomics using causative drug-exposed peripheral blood cells", THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY: IN PRACTICE, vol. 7, no. 8, November 2019 (2019-11-01), pages 2894 - 2897, XP009531087, ISSN: 10.1016/j.jaip.2019.05.002, DOI: 2213-2198
KOMATSU-FUJII TAKAYOSHI, YUKO CHINUKI, HIROYUKI NIIHARA, KENJI HAYASHIDA, MASATAKA OHTA, RYOTA OKAZAKI, SAKAE KANEKO, EISHIN MORIT: "The thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption is a prognostic biomarker of severity of systemic inflammation", ALLERGOLOGY INTERNATIONAL, vol. 67, no. 1, 22 June 2017 (2017-06-22), pages 90 - 95, XP055858035, DOI: 10.1016/j.alit.2017.06.001
KOMATSU-FUJII T ET AL.: "The thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption is a prognostic biomarker of severity of systemic inflammation", ALLERGOLOGY INT., vol. 67, 2018, pages 90 - 95, XP055858035, DOI: 10.1016/j.alit.2017.06.001
ABE R ET AL.: "Rapid immunochromatographic test for serum granulysin is useful for the prediction of Stevens-Johnson syndrome and toxic epidermal necrolysis", J AM ACAD DERMATOL., vol. 65, no. 1, 2011, pages 65 - 8, XP028240461, DOI: 10.1016/j.jaad.2010.04.042
SHIOHARA T ET AL.: "Monitoring the acute response in severe hypersensitivity reactions to drugs", CURR OPIN ALLERGY CLIN IMMUNOL., vol. 15, no. 4, 2015, pages 294 - 9
SHIBA-ISHII ANOGUCHI M: "Aberrant stratifin overexpression is regulated by tumor-associated CpG demethylation in lung adenocarcinoma", AM J PATHOL., vol. 180, no. 4, April 2012 (2012-04-01), pages 1653 - 62
JUNICHI TAMARU, CD30: "Clinical Test Update", MODERN MEDIA, vol. 60, no. 11, 2015
"UniProt", Database accession no. 095407
NATURE REVIEWS, DRUG DISCOVERY, vol. 1, December 2002 (2002-12-01), pages 951 - 960
NATURE REVIEWS, DRUG DISCOVERY, vol. 1, September 2002 (2002-09-01), pages 683 - 695
NATURE REVIEWS, DRUG DISCOVERY, vol. 1, June 2002 (2002-06-01), pages 447 - 456
MICHAELETTI RG ET AL., J INVEST DERMATOL., vol. 138, 2018, pages 2315 - 2321
WOLFSON AR ET AL., J ALLERGY CLIN IMMUNOL PRACT., vol. 7, 2019, pages 633 - 640
HAMA NATSUMI, NISHIMURA KEIKO, HASEGAWA AKITO, YUKI AKIHIKO, KUME HIDEAKI, ADACHI JUN, KINOSHITA MANAO, OGAWA YOUICHI, NAKAJIMA SA: "Galectin-7 as a potential biomarker of Stevens-Johnson syndrome/toxic epidermal necrolysis: identification by targeted proteomics using causative drug-exposed peripheral blood cells", THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY: IN PRACTICE, vol. 7, no. 8, November 2019 (2019-11-01), pages 2894 - 2897, XP009531087, ISSN: 10.1016/j.jaip.2019.05.002, DOI: 2213-2198
KOMATSU-FUJII TAKAYOSHI, YUKO CHINUKI, HIROYUKI NIIHARA, KENJI HAYASHIDA, MASATAKA OHTA, RYOTA OKAZAKI, SAKAE KANEKO, EISHIN MORIT: "The thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption is a prognostic biomarker of severity of systemic inflammation", ALLERGOLOGY INTERNATIONAL, vol. 67, no. 1, 22 June 2017 (2017-06-22), pages 90 - 95, XP055858035, DOI: 10.1016/j.alit.2017.06.001
KOMATSU-FUJII T ET AL.: "The thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption is a prognostic biomarker of severity of systemic inflammation", ALLERGOLOGY INT., vol. 67, 2018, pages 90 - 95, XP055858035, DOI: 10.1016/j.alit.2017.06.001
ABE R ET AL.: "Rapid immunochromatographic test for serum granulysin is useful for the prediction of Stevens-Johnson syndrome and toxic epidermal necrolysis", J AM ACAD DERMATOL., vol. 65, no. 1, 2011, pages 65 - 8, XP028240461, DOI: 10.1016/j.jaad.2010.04.042
SHIOHARA T ET AL.: "Monitoring the acute response in severe hypersensitivity reactions to drugs", CURR OPIN ALLERGY CLIN IMMUNOL., vol. 15, no. 4, 2015, pages 294 - 9
SHIBA-ISHII ANOGUCHI M: "Aberrant stratifin overexpression is regulated by tumor-associated CpG demethylation in lung adenocarcinoma", AM J PATHOL., vol. 180, no. 4, April 2012 (2012-04-01), pages 1653 - 62
JUNICHI TAMARU, CD30: "Clinical Test Update", MODERN MEDIA, vol. 60, no. 11, 2015
"UniProt", Database accession no. 095407
NATURE REVIEWS, DRUG DISCOVERY, vol. 1, December 2002 (2002-12-01), pages 951 - 960
NATURE REVIEWS, DRUG DISCOVERY, vol. 1, September 2002 (2002-09-01), pages 683 - 695
NATURE REVIEWS, DRUG DISCOVERY, vol. 1, June 2002 (2002-06-01), pages 447 - 456
MICHAELETTI RG ET AL., J INVEST DERMATOL., vol. 138, 2018, pages 2315 - 2321
WOLFSON AR ET AL., J ALLERGY CLIN IMMUNOL PRACT., vol. 7, 2019, pages 633 - 640
Attorney, Agent or Firm:
MAYAMA, Setsuko et al. (JP)
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