Title:
PROTEIN-ENCAPSULATED SELF-REPLICATING RNA AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/221938
Kind Code:
A1
Abstract:
The present invention provides a protein-encapsulated self-replicating RNA and a preparation method therefor. The protein-encapsulated self-replicating RNA is obtained by culturing recombinant cells. A recombinant cell comprises: a first nucleic acid molecule, the first nucleic acid molecule comprising a self-replicating RNA molecule; and a second nucleic acid molecule, the second nucleic acid molecule encoding a delivery vector protein.
Inventors:
WU KEXING (CN)
Application Number:
PCT/CN2023/094280
Publication Date:
November 23, 2023
Filing Date:
May 15, 2023
Export Citation:
Assignee:
R&R THERAPEUTICS INC (CN)
International Classes:
C12N5/10; C12N15/47; C12N15/85
Domestic Patent References:
| WO2022009049A1 | 2022-01-13 |
Foreign References:
| CN1575339A | 2005-02-02 | |||
| US20210363543A1 | 2021-11-25 | |||
| CN111601605A | 2020-08-28 | |||
| US20210290752A1 | 2021-09-23 | |||
| CN103052400A | 2013-04-17 |
Other References:
SHEN JIANLI, GONG ZUXUN : "Advances of Research on Molecular Biology of Rhabdoviridae Ⅱ. Viral Structural Protein, Transcription, Replication and Capsidation", VIROLOGICA SINICA, SPRINGER, DE, vol. 13, no. 4, 31 December 1998 (1998-12-31), DE , pages 281 - 291, XP009550373, ISSN: 1003-5125
LUNDSTROM KENNETH: "Self-replicating vehicles based on negative strand RNA viruses", CANCER GENE THERAPY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 30, no. 6, 1 June 2023 (2023-06-01), New York, pages 771 - 784, XP093108123, ISSN: 0929-1903, DOI: 10.1038/s41417-022-00436-7
LUNDSTROM KENNETH: "Self-replicating vehicles based on negative strand RNA viruses", CANCER GENE THERAPY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 30, no. 6, 1 June 2023 (2023-06-01), New York, pages 771 - 784, XP093108123, ISSN: 0929-1903, DOI: 10.1038/s41417-022-00436-7
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
Download PDF:
Previous Patent: METHOD FOR DELIVERING SELF-REPLICATING RNA MOLECULE
Next Patent: NOVEL COMPOSITIONS AND METHODS FOR CELL-FREE DNA DETECTION
Next Patent: NOVEL COMPOSITIONS AND METHODS FOR CELL-FREE DNA DETECTION