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Title:
PROTEIN, AND ISOLATION METHOD FOR ANTIBODIES OR FRAGMENTS THEREOF USING CARRIER INCLUDING SAID PROTEIN
Document Type and Number:
WIPO Patent Application WO/2019/039602
Kind Code:
A1
Abstract:
Provided is a carrier for affinity chromatography having high immunoglobulin purification efficiency. This protein contains two or more domains linked together by a linker. The domains have affinity to immunoglobulins. The linker is a peptide having a rod-shaped structure, or the linker includes (a) a linker comprising a polypeptide containing at least one proline and/or (b) a linker comprising a polypeptide including at least one peptide unit comprising Xa-(A)i-Xb or Xb-(A)i-Xa (where Xa represents an acidic amino acid, Xb represents a basic amino acid, A represents alanine, and i represents an integer of 3 or 4).

Inventors:
ICHII TAKASHI (JP)
KANAHARA MASAAKI (JP)
HAGA TOMOAKI (JP)
Application Number:
PCT/JP2018/031432
Publication Date:
February 28, 2019
Filing Date:
August 24, 2018
Export Citation:
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Assignee:
JSR CORP (JP)
JSR LIFE SCIENCES CORP (JP)
JSR MICRO INC (US)
JSR MICRO N V (BE)
International Classes:
C12N15/09; C07K1/22; C07K14/31; C07K17/02; C12N1/15; C12N1/19; C12N1/21; C12N5/10; G01N30/88
Domestic Patent References:
WO2015050153A12015-04-09
WO2010080424A12010-07-15
WO2013018880A12013-02-07
WO2016152946A12016-09-29
WO2010110288A12010-09-30
Foreign References:
JP2009297018A2009-12-24
JP2015019615A2015-02-02
Other References:
LEE J H. ET AL.: "Enhancing immunoassay detection of antigens with multimeric protein Gs", BIOSENSORS AND BIOELECTRONICS, vol. 28, no. 1, 2011, pages 146 - 151, XP028340765, DOI: doi:10.1016/j.bios.2011.07.011
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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