Title:
PROTEOGLYCAN ISOLATED FROM CARTILAGINOUS FISH AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2004/083257
Kind Code:
A1
Abstract:
It is intended to provide a cartilage extract which exerts its effect even in the case of taking in a small amount and shows a definite function mechanism of the effect. Namely, isolated proteoglycan which originates in a water extract of the cartilage of a cartilaginous fish and the main component of which has a molecular weight of 500 kDa or higher; a composition containing this proteoglycan; a medicinal composition containing the proteoglycan as the active ingredient; and a process for producing the proteoglycan which comprises the step of grinding the cartilage of a cartilaginous fish into pieces of an average diameter of 100 μm or less, the step of adding water to the ground matter and extracting water-soluble components therefrom, the step of separating the aqueous phase containing the water-soluble components, and the step of adding an alcohol to the aqueous phase and obtaining the precipitate.
Inventors:
SATO KENJI (JP)
TSUTSUMI MASAHIRO (JP)
NOMURA YOSHIHIRO (JP)
MURATA NAO (JP)
KONDO NAOYUKI (JP)
TSUTSUMI MASAHIRO (JP)
NOMURA YOSHIHIRO (JP)
MURATA NAO (JP)
KONDO NAOYUKI (JP)
Application Number:
PCT/JP2004/003432
Publication Date:
September 30, 2004
Filing Date:
March 15, 2004
Export Citation:
Assignee:
HOSOKAWA MICRON KK (JP)
SATO KENJI (JP)
TSUTSUMI MASAHIRO (JP)
NOMURA YOSHIHIRO (JP)
MURATA NAO (JP)
KONDO NAOYUKI (JP)
SATO KENJI (JP)
TSUTSUMI MASAHIRO (JP)
NOMURA YOSHIHIRO (JP)
MURATA NAO (JP)
KONDO NAOYUKI (JP)
International Classes:
A61K35/60; A61P17/06; A61P19/02; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P43/00; C07K14/46; C08B37/00; (IPC1-7): C08B37/08; A61K38/55; A61P17/06; A61P19/02; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P43/00; C07K14/46; C12P21/00
Foreign References:
| JP2003300858A | 2003-10-21 | |||
| JPH11502514A | 1999-03-02 | |||
| JPH09512563A | 1997-12-16 | |||
| US4473551A | 1984-09-25 |
Other References:
NAHO MURATA: "N-nitr osobis 2-oxopr opyl) amine ni yoru hamster suikan gan hassei ni taisuru ushi oyobi same nankotsusui chushutsubutsu no eikyo", JOURNAL OF NARA MEDICAL ASSOCIATION, vol. 53, no. 5,6, 2002, pages 241 - 252, XP002979606
MUSASHI KITAHASHI ET AL.: "Same nankotsu chushutsubutsu o sesshu shita hamster ketsuekichu no matrix metalloprotease (MMPs) to serine protease-ryo oyobi sogai kassei no henka", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY AND AGROCHEMISTRY (2A17P18), 5 March 2003 (2003-03-05), pages 63, XP002982789
See also references of EP 1614697A4
MUSASHI KITAHASHI ET AL.: "Same nankotsu chushutsubutsu o sesshu shita hamster ketsuekichu no matrix metalloprotease (MMPs) to serine protease-ryo oyobi sogai kassei no henka", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY AND AGROCHEMISTRY (2A17P18), 5 March 2003 (2003-03-05), pages 63, XP002982789
See also references of EP 1614697A4
Attorney, Agent or Firm:
Suzuki, Takao (Nishinakajima 7-chome Yodogawa-ku, Osaka-sh, Osaka 11, JP)
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