Title:
PROTEOGLYCAN PRODUCTION ACCELERATOR
Document Type and Number:
WIPO Patent Application WO/2008/023796
Kind Code:
A1
Abstract:
Disclosed is a compound represented by the formula (I) below, which selectively accelerates biosynthesis of a proteoglycan, particularly a chondroitin sulfate proteoglycan or a heparan sulfate proteoglycan. Also disclosed is a pharmaceutical product containing such a compound as an active ingredient. (I) (In the formula, R represents a hydrogen atom, an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, or a peptide residue composed of a natural or non-natural amino acid; and X and Y represent a halogen atom, a hydroxy group or an alkoxy group. In this connection, at least one of X and Y represents a hydroxy group, but both X and Y are not hydroxy groups at the same time.)
Inventors:
NISHIMURA SHIN-ICHIRO
Application Number:
PCT/JP2007/066459
Publication Date:
February 28, 2008
Filing Date:
August 24, 2007
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
SHIONOGI & CO (JP)
NISHIMURA SHIN-ICHIRO
SHIONOGI & CO (JP)
NISHIMURA SHIN-ICHIRO
International Classes:
C07K5/062; A61K31/702; A61K38/00; A61P17/02; A61P19/02; C07H3/06
Domestic Patent References:
| WO2004076476A1 | 2004-09-10 |
Foreign References:
| JP2006063055A | 2006-03-09 | |||
| JP2006111618A | 2006-04-27 |
Other References:
SHIMAWAKI K. ET AL.: "Proteoglycan Seigosei Kiko no Yuki Goseiteki Kaimei", POLYMER PREPRINTS, JAPAN, vol. 54, no. 1, 10 May 2005 (2005-05-10), pages 1PF190, XP003024666
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (IMP Building3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka 01, JP)
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