Title:
PTPRK IMMUNOGENIC PEPTIDE
Document Type and Number:
WIPO Patent Application WO2004043988
Kind Code:
A3
Abstract:
An immunogenic peptide isolated from PTPRK protein represents a novel HLA II restricted epitope recognized by CD4+T cells and is used in cancer immunotherapy or diagnosis.
Inventors:
CASTELLI CHIARA (IT)
PARMIANI GIORGIO (IT)
PARMIANI GIORGIO (IT)
Application Number:
PCT/EP2003/012638
Publication Date:
October 14, 2004
Filing Date:
November 12, 2003
Export Citation:
Assignee:
IST NAZ STUD CURA DEI TUMORI (IT)
CASTELLI CHIARA (IT)
PARMIANI GIORGIO (IT)
CASTELLI CHIARA (IT)
PARMIANI GIORGIO (IT)
International Classes:
A61K39/00; C07K14/47; C07K14/74; C07K16/32; C12N5/07; C12N5/0783; C12N5/09; C12Q1/68; G01N33/574; C07K; (IPC1-7): C07K14/47; C07K16/32; A61K39/00; C12Q1/68
Domestic Patent References:
| WO1994024161A1 | 1994-10-27 |
Other References:
NOVELLINO LUISA ET AL: "Identification of a mutated receptor-like protein tyrosine phosphatase kappa as a novel, class II HLA-restricted melanoma antigen.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 JUN 2003, vol. 170, no. 12, 15 June 2003 (2003-06-15), pages 6363 - 6370, XP002291065, ISSN: 0022-1767
ZHANG Y ET AL: "Cytogenetical Assignment and Physical Mapping of the Human R-PTP-kappa Gene (PTPRK) to the Putative Tumor Suppressor Gene Region 6q22.2-q22.3", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 51, no. 2, 15 July 1998 (1998-07-15), pages 309 - 311, XP004449104, ISSN: 0888-7543
YANG YOUNG ET AL: "Transforming growth factor-beta-1 inhibits human keratinocyte proliferation by upregulation of a receptor-type tyrosine phosphatase R-PTP-kappa gene expression", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 228, no. 3, 1996, pages 807 - 812, XP002291066, ISSN: 0006-291X
NAKAMURA MITSUTOSHI ET AL: "Novel tumor suppressor loci on 6q22-23 in primary central nervous system lymphomas.", CANCER RESEARCH, vol. 63, no. 4, 15 February 2003 (2003-02-15), pages 737 - 741, XP002291067, ISSN: 0008-5472
ZHANG Y ET AL: "Cytogenetical Assignment and Physical Mapping of the Human R-PTP-kappa Gene (PTPRK) to the Putative Tumor Suppressor Gene Region 6q22.2-q22.3", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 51, no. 2, 15 July 1998 (1998-07-15), pages 309 - 311, XP004449104, ISSN: 0888-7543
YANG YOUNG ET AL: "Transforming growth factor-beta-1 inhibits human keratinocyte proliferation by upregulation of a receptor-type tyrosine phosphatase R-PTP-kappa gene expression", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 228, no. 3, 1996, pages 807 - 812, XP002291066, ISSN: 0006-291X
NAKAMURA MITSUTOSHI ET AL: "Novel tumor suppressor loci on 6q22-23 in primary central nervous system lymphomas.", CANCER RESEARCH, vol. 63, no. 4, 15 February 2003 (2003-02-15), pages 737 - 741, XP002291067, ISSN: 0008-5472
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