Title:
PULMONARY FIBROSIS TREATMENT AGENT, PTPRR EXPRESSION-PROMOTING AGENT, AND KIT FOR PULMONARY FIBROSIS TREATMENT
Document Type and Number:
WIPO Patent Application WO/2018/151046
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel treatment agent for pulmonary fibrosis for which there is currently no effective drug therapy established. The present invention is a pulmonary fibrosis treatment agent containing mesenchymal stem cells. The pulmonary fibrosis is preferably usual interstitial pneumonia (UIP) or idiopathic pulmonary fibrosis (IPF). Also, the mesenchymal stem cells are preferably derived from adipose tissue or are allogeneic.
Inventors:
FURUNO TETSUO (JP)
ITO TOSHIHIRO (JP)
KIMURA HIROSHI (JP)
YOSHIKAWA MASANORI (JP)
SAWADA MAKIKO (JP)
ITO TOSHIHIRO (JP)
KIMURA HIROSHI (JP)
YOSHIKAWA MASANORI (JP)
SAWADA MAKIKO (JP)
Application Number:
PCT/JP2018/004623
Publication Date:
August 23, 2018
Filing Date:
February 09, 2018
Export Citation:
Assignee:
ROHTO PHARMA (JP)
PUBLIC UNIV CORPORATION NARA MEDICAL UNIV (JP)
PUBLIC UNIV CORPORATION NARA MEDICAL UNIV (JP)
International Classes:
A61K35/28; A61K45/00; A61P11/00; A61P43/00
Domestic Patent References:
| WO2007058308A1 | 2007-05-24 |
Foreign References:
| JP2014533961A | 2014-12-18 | |||
| JP2010500047A | 2010-01-07 | |||
| JP2002506831A | 2002-03-05 | |||
| JP2000508911A | 2000-07-18 | |||
| JP2012157263A | 2012-08-23 | |||
| JP2012508733A | 2012-04-12 | |||
| US6777231B1 | 2004-08-17 |
Other References:
KUBO, HIROSHI : "Lung regeneration and stem cells", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE = IGAKU NO AYUMI, 15 April 2013 (2013-04-15), pages 58 - 60, XP009516295, ISSN: 0039-2359
WANG, J. ET AL.: "Inhibition of hepatic stellate cells proliferation by mesenchymal stem cells and the possible mechanisms", HEPATOLOGY RESEARCH, vol. 39, no. 12, December 2009 (2009-12-01), pages 1219 - 1228, XP055537370
"The Merck Manual of Diagnosis and Therapy", 22 February 2007, NIKKEI BP, pages: 466 - 471
TIMOTHY S. B. ET AL., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 189, no. 2, 2014, pages 214 - 222
PITTENGER F. M. ET AL., SCIENCE, vol. 284, 1999, pages 143 - 147
See also references of EP 3583945A4
WANG, J. ET AL.: "Inhibition of hepatic stellate cells proliferation by mesenchymal stem cells and the possible mechanisms", HEPATOLOGY RESEARCH, vol. 39, no. 12, December 2009 (2009-12-01), pages 1219 - 1228, XP055537370
"The Merck Manual of Diagnosis and Therapy", 22 February 2007, NIKKEI BP, pages: 466 - 471
TIMOTHY S. B. ET AL., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 189, no. 2, 2014, pages 214 - 222
PITTENGER F. M. ET AL., SCIENCE, vol. 284, 1999, pages 143 - 147
See also references of EP 3583945A4
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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