Title:
PURIFICATION METHOD FOR IMIDAZOLE DIPEPTIDES
Document Type and Number:
WIPO Patent Application WO/2021/221085
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for mass-producing individual imidazole dipeptides at high purity and on an industrial scale regardless of the kind of an animal extract. This purpose is achieved by a method for producing purified imidazole dipeptides, said method comprising the following steps (1) and (2): (1) a step for subjecting a treated animal extract liquid, which contains at least two kinds of imidazole dipeptides, to an adsorption treatment by contacting with a hydrophobic adsorbent resin and thus allowing the hydrophobic adsorbent resin to adsorb the imidazole dipeptides; and (2) a step for subjecting the hydrophobic adsorbent resin, which carries the imidazole dipeptides adsorbed thereon, to an elution treatment using an aqueous solution and collecting the at least two kinds of imidazole dipeptides separately from each other to thereby purify the imidazole dipeptides.
Inventors:
YONEYAMA AKIRA (JP)
SANO CHIAKI (JP)
NAKANISHI HIROKI (JP)
KAWAI YOSHIO (JP)
KOYAMA YOHSUKE (JP)
SANO CHIAKI (JP)
NAKANISHI HIROKI (JP)
KAWAI YOSHIO (JP)
KOYAMA YOHSUKE (JP)
Application Number:
PCT/JP2021/016910
Publication Date:
November 04, 2021
Filing Date:
April 28, 2021
Export Citation:
Assignee:
TOKAI BUSSAN CO LTD (JP)
International Classes:
C07K1/20; C07K1/18; C07K5/06
Foreign References:
| JP2005247765A | 2005-09-15 | |||
| JP2002153702A | 2002-05-28 | |||
| JP2010235503A | 2010-10-21 |
Other References:
SHIOTANI SHIGENOBU, SUZUKI TAKANORI, YONEYAMA AKIRA, YANAI NOBUYA, HAGIWARA SHOJI, NABETANI HIROSHI: "An Improved Reverse Phase High Performance Liquid Chromatography Method for Simultaneous Quantification of Levels of Imidazole Dipeptides and Their Metabolites in Human Plasma", JOURNAL OF JAPANESE SOCIETY OF FOOD SCIENCE AND TECHNOLOGY, NIPPON SHOKUHIN KAGAKU KOGAKUKAI, TSUKUBA, JP, vol. 64, no. 8, 1 January 2017 (2017-01-01), JP , pages 437 - 445, XP055868905, ISSN: 1341-027X, DOI: 10.3136/nskkk.64.437
O'DOWD JOHN, MARIA T. CAIRNS, MAXINE TRAINOR, DAVID J. ROBINS, DAVID J. MILLER: "Analysis of Carnosine, Homocarnosine, and Other Histidyl Derivatives in Rat Brain", JOURNAL OF NEUROCHEMISTRY, vol. 55, no. 2, 31 August 1990 (1990-08-31), pages 446 - 452, XP055868907, DOI: 10.1111/j.1471-4159.1990.tb04156.x
O'DOWD JOHN, MARIA T. CAIRNS, MAXINE TRAINOR, DAVID J. ROBINS, DAVID J. MILLER: "Analysis of Carnosine, Homocarnosine, and Other Histidyl Derivatives in Rat Brain", JOURNAL OF NEUROCHEMISTRY, vol. 55, no. 2, 31 August 1990 (1990-08-31), pages 446 - 452, XP055868907, DOI: 10.1111/j.1471-4159.1990.tb04156.x
Attorney, Agent or Firm:
MORIMOTO, Toshiaki (JP)
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