Title:
PURINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2017/209267
Kind Code:
A1
Abstract:
The present invention provides a novel compound having a P2X3 and/or P2X2/3 receptor antagonistic activity.
A compound represented by formula (I) (wherein R1a represents a substituted or unsubstituted alkyl group or the like; R1b represents a hydrogen atom or the like; R2 represents a substituted or unsubstituted aromatic carbocyclic group or the like; R3 represents a halogen atom or the like; R4a's independently represent a hydrogen atom or the like; R4b's independently represent a hydrogen atom or the like; n represents an integer of 0 to 4; X represents -N(R5)- or the like; R5 represents a hydrogen atom or the like; and s represents an integer of 0 to 3) or a pharmaceutically acceptable salt thereof.
Inventors:
KAI HIROYUKI (JP)
FUJIOKA MASAHIKO (JP)
FUJIOKA MASAHIKO (JP)
Application Number:
PCT/JP2017/020535
Publication Date:
December 07, 2017
Filing Date:
June 02, 2017
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07D473/18; A61K31/522; A61P11/00; A61P13/02; A61P25/04; A61P43/00
Domestic Patent References:
| WO2016088838A1 | 2016-06-09 | |||
| WO2012020742A1 | 2012-02-16 | |||
| WO2010111058A1 | 2010-09-30 | |||
| WO2008136756A1 | 2008-11-13 | |||
| WO2013175231A1 | 2013-11-28 |
Other References:
MARCHENKOVA,A. ET AL.: "Brain natriuretic peptide constitutively downregulates P2X3 receptors by controlling their phosphorylation state and membrane localization", MOLECULAR PAIN, vol. 11, 2015, pages 71/1 - 71/16, XP055445501, ISSN: 1744-8069
Attorney, Agent or Firm:
YAMAUCHI, Hideaki et al. (JP)
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