Title:
PYRANOGLUCOSE-SUBSTITUTED PYRAZOLE COMPOUND, PREPARATION METHOD THEREOF AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/141209
Kind Code:
A1
Abstract:
A pyranoglucose-substituted pyrazole compound, used as a pharmaceutical intermediate, having the structural formula represented by formula (9c). The present invention further relates to an intermediate compound represented by formula (10c) or a salt thereof. The present invention further relates to a preparation method of the aforementioned intermediate compound and a method of using the same to prepare an SGLT inhibitor. By means of the novel key intermediate, the preparation technique of an SGLT inhibitor is greatly simplified. In addition, because the intermediate can be precipitated in the form of a salt and is easy to purify, the purity of the SGLT inhibitor is significantly increased, compared with the original preparation pathway (crude product purity can reach 99% or more). (I)
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Inventors:
ZHANG FEI (CN)
WANG PENG (CN)
SUN LILI (CN)
ZHU LIN (CN)
WANG PENG (CN)
SUN LILI (CN)
ZHU LIN (CN)
Application Number:
PCT/CN2019/072148
Publication Date:
July 25, 2019
Filing Date:
January 17, 2019
Export Citation:
Assignee:
YABAO PHARMACEUTICAL GROUP CO LTD (CN)
SUZHOU YABAO PHARMACEUTICAL R&D CO LTD (CN)
SUZHOU YABAO PHARMACEUTICAL R&D CO LTD (CN)
International Classes:
C07H17/02; A61K31/7056; A61P3/10
Domestic Patent References:
| WO2014055297A1 | 2014-04-10 |
Foreign References:
| CN105705509A | 2016-06-22 | |||
| CN104284894A | 2015-01-14 | |||
| CN201810052483A | 2018-01-18 | |||
| CN105705509A | 2016-06-22 | |||
| CN105705509A | 2016-06-22 |
Other References:
See also references of EP 3741771A4
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
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