PYRAZINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF AS ADENOSINE ANTAGONISTS

Title:

PYRAZINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF AS ADENOSINE ANTAGONISTS

Document Type and Number:

WIPO Patent Application WO2005095384

Kind Code:

A8

Abstract:

A pyrazine derivative of the following formula (I): wherein is hydrogen or optionally substituted lower alkyl; X,is hydrogen, halogen, hydroxy, cyano, acyl, or amino, aryl, heterocyclic group or the like; Y is hydrogen, halogen, hydroxy, acyl, amino, or the like; Z is aryl_. or heteroaryl, each of which is optionallysubstituted; or a salt thereof. The pyrazine compound (I) and a salt thereof of the present invention are adenosine antagonists and are useful for the prevention and/or treatment of depression, dementia (e.g. Alzheimer's disease, cerebrovascular dementia, dementia accompanying Parkinson's disease, etc.), Parkinson's disease,anxiety, pain, cerebrovascular disease (e.g. stroke, etc.), heart failure and the like.

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Inventors:

TSUTSUMI HIDEO (JP)
TABUCHI SEIICHIRO (JP)
MINAGAWA MASATOSHI (JP)
AKAHANE ATSUSHI (JP)

Application Number:

PCT/JP2005/005663

Publication Date:

October 26, 2006

Filing Date:

March 22, 2005

Export Citation:

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Assignee:

ASTELLAS PHARMA INC (JP)
TSUTSUMI HIDEO (JP)
TABUCHI SEIICHIRO (JP)
MINAGAWA MASATOSHI (JP)
AKAHANE ATSUSHI (JP)

International Classes:

C07D403/04; C07D401/14; C07D403/14; C07D405/14; C07D409/14; C07D413/04; C07D417/14; C07D487/04; C07D498/08

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