PYRAZOLE DERIVATIVES - DAIICHI SEIYAKU CO

Title:

PYRAZOLE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1998/032739

Kind Code:

A1

Abstract:

Compounds represented by general formula (I) and salts thereof and an antitumor agent comprising the same as the active ingredient: wherein R?1� and R?2� each is hydrogen, halogeno, hydroxy, alkoxy, amino, alkylamino, aryl, or alkyl; R?3� and R?4� each is hydrogen, halogeno, alkoxy, amino, alkylamino, aryl, or alkyl; R?5� is hydrogen, alkyl, alkenyl, alkynyl, aryl, or arylalkyl; Q is amidino, cycloalkyl, phenyl, or monocyclic heterocycle (excluding pyrimidinyl bonded at the 2-position); G is a nitrogenous saturated heterocyclic structure represented by formula (1) wherein X?1� is nitrogen or CH, which may contain a ketone moiety and may have one or more substituents on the ring; Z is phenyl or heterocycle which each may have one or more substituents and in which two substituents may be bonded to each other to form a fused dicyclic structure; and a substituent of Z and a substituent of G may be bonded to each other to form a fused tricyclic or tetracyclic structure together with G and Z.

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Inventors:

EJIMA AKIO (JP)
OHSUKI SATORU (JP)

Application Number:

PCT/JP1998/000300

Publication Date:

July 30, 1998

Filing Date:

January 26, 1998

Export Citation:

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Assignee:

DAIICHI SEIYAKU CO (JP)
EJIMA AKIO (JP)
OHSUKI SATORU (JP)

International Classes:

C07D231/12; C07D401/04; C07D403/04; C07D417/04; (IPC1-7): C07D231/12; A61K31/495; A61K31/505; A61K31/53; C07D401/04; C07D417/04; C07D403/03

Foreign References:

JPS62205058A	1987-09-09
JPS6388179A	1988-04-19

Other References: