Title:
PYRAZOLE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1999/019303
Kind Code:
A1
Abstract:
Drugs, in particular, pyrazole derivatives represented by general formula (I) which have a calcium release-dependent calcium channel inhibitory effect and medicinal compositions, in particular, calcium release-dependent calcium channel inhibitors containing the above compounds as the active ingredient, in said formula each symbol has the following meaning: B: phenylene, a nitrogen-containing, divalent, saturated ring group, or an optionally alkylated, monocyclic, divalent heteroaromatic ring group; X: -NR?1¿-CR?2¿R?3¿-, -CR?2¿R?3¿-NR?1¿-, -NR?1¿-SO¿2?-, -SO¿2?-NR?1¿- or -CR?4¿=CR?5¿-; and A: phenyl optionally having one or more substituents; mono-, di- or tricyclic fused heteroaryl optionally having one or more substituents; cycloalkyl optionally having one or more substituents; a nitrogen-containing, saturated ring group optionally having one or more substituents; lower alkenyl optionally having one or more substituents; lower alkynyl optionally having one or more substituents; or alkyl optionally having one or more substituents.
Inventors:
KUBOTA HIROKAZU (JP)
YONETOKU YASUHIRO (JP)
SUGASAWA KEIZOU (JP)
FUNATSU MASASHI (JP)
KAWAZOE SOUICHIROU (JP)
TOYOSHIMA AKIRA (JP)
OKAMOTO YOSHINORI (JP)
ISHIKAWA JUN (JP)
TAKEUCHI MAKOTO (JP)
YONETOKU YASUHIRO (JP)
SUGASAWA KEIZOU (JP)
FUNATSU MASASHI (JP)
KAWAZOE SOUICHIROU (JP)
TOYOSHIMA AKIRA (JP)
OKAMOTO YOSHINORI (JP)
ISHIKAWA JUN (JP)
TAKEUCHI MAKOTO (JP)
Application Number:
PCT/JP1998/004583
Publication Date:
April 22, 1999
Filing Date:
October 12, 1998
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
KUBOTA HIROKAZU (JP)
YONETOKU YASUHIRO (JP)
SUGASAWA KEIZOU (JP)
FUNATSU MASASHI (JP)
KAWAZOE SOUICHIROU (JP)
TOYOSHIMA AKIRA (JP)
OKAMOTO YOSHINORI (JP)
ISHIKAWA JUN (JP)
TAKEUCHI MAKOTO (JP)
KUBOTA HIROKAZU (JP)
YONETOKU YASUHIRO (JP)
SUGASAWA KEIZOU (JP)
FUNATSU MASASHI (JP)
KAWAZOE SOUICHIROU (JP)
TOYOSHIMA AKIRA (JP)
OKAMOTO YOSHINORI (JP)
ISHIKAWA JUN (JP)
TAKEUCHI MAKOTO (JP)
International Classes:
A61K31/4155; A61K31/416; A61K31/427; A61K31/433; A61K31/4439; A61K31/538; C07D231/12; C07D231/14; C07D401/12; C07D403/12; C07D409/04; C07D409/12; C07D409/14; C07D413/02; C07D417/02; C07D417/04; C07D417/12; C07D417/14; C07D521/00; (IPC1-7): C07D231/12; C07D231/14; C07D401/04; C07D401/14; C07D403/12; C07D409/04; C07D413/04; C07D413/12; C07D417/04; C07D417/12; C07D417/14; A61K31/415; A61K31/425; A61K31/44; A61K31/47; A61K31/495; A61K31/535
Foreign References:
| JPH03141261A | 1991-06-17 | |||
| JPH01287071A | 1989-11-17 | |||
| JPH04234851A | 1992-08-24 |
Other References:
See also references of EP 1024138A4
Attorney, Agent or Firm:
Nagai, Shozo (Ltd. Patent Dept. 17-1, Hasune 3-chome Itabashi-ku Tokyo, JP)
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