Title:
PYRIDAZINONES AND TRIAZINONES AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2002/022587
Kind Code:
A1
Abstract:
Provided are novel compounds exhibiting excellent inhibitory activities against AMPA receptor and/or kainate receptor, i.e., compounds of the general formula (I), salts thereof, or hydrates of both wherein A?1¿, A?2¿ and A?3¿ are each independently C¿3-8? cycloalkyl, C¿3-8? cycloalkenyl, a 5- to 14-membered nonoaromatic heterocyclic group, a C¿6-14? aromatic carbocyclic group, or a 5- to 14-membered aromatic heterocyclic group, any of which may be substituted; Q is O, S, or NH; Z is C or N; X?1¿, X?2¿ and X?3¿ are each independently a single bond, optionally substituted C¿1-6? alkylene, optionally substituted C¿2-6? alkenylene, optionally substituted C¿2-6? alkynylene, -NH-, -O-, -NHCO-, -CONH-, -SO¿0-2?-, or the like; R?1¿ and R?2¿ are each independently hydrogen or optionally substituted C¿1-6? alkyl, or alternatively R?1¿ and R?2¿ may be united in such a way that CR?2¿-ZR?1¿ forms C=C; and R?3¿ is hydrogen, optionally substituted C¿1-6? alkyl, or the like, or alternatively R?3¿ may unite with any atom on the ring A?1¿ or A?3¿ to form together with the atom an optionally substituted C¿5-8? carbocycle or an optionally substituted 5- to 8-membered heterocycle.
Inventors:
NAGATO SATOSHI (JP)
KAWANO KOKI (JP)
ITO KOICHI (JP)
NORIMINE YOSHIHIKO (JP)
UENO KOHSHI (JP)
HANADA TAKAHISA (JP)
AMINO HIROYUKI (JP)
OGO MAKOTO (JP)
HATAKEYAMA SHINJI (JP)
UENO MASATAKA (JP)
GROOM ANTHONY JOHN (GB)
RIVERS LEANNE (GB)
SMITH TERENCE (GB)
KAWANO KOKI (JP)
ITO KOICHI (JP)
NORIMINE YOSHIHIKO (JP)
UENO KOHSHI (JP)
HANADA TAKAHISA (JP)
AMINO HIROYUKI (JP)
OGO MAKOTO (JP)
HATAKEYAMA SHINJI (JP)
UENO MASATAKA (JP)
GROOM ANTHONY JOHN (GB)
RIVERS LEANNE (GB)
SMITH TERENCE (GB)
Application Number:
PCT/JP2001/008058
Publication Date:
March 21, 2002
Filing Date:
September 17, 2001
Export Citation:
Assignee:
EISAI CO LTD (JP)
NAGATO SATOSHI (JP)
KAWANO KOKI (JP)
ITO KOICHI (JP)
NORIMINE YOSHIHIKO (JP)
UENO KOHSHI (JP)
HANADA TAKAHISA (JP)
AMINO HIROYUKI (JP)
OGO MAKOTO (JP)
HATAKEYAMA SHINJI (JP)
UENO MASATAKA (JP)
GROOM ANTHONY JOHN (GB)
RIVERS LEANNE (GB)
SMITH TERENCE (GB)
NAGATO SATOSHI (JP)
KAWANO KOKI (JP)
ITO KOICHI (JP)
NORIMINE YOSHIHIKO (JP)
UENO KOHSHI (JP)
HANADA TAKAHISA (JP)
AMINO HIROYUKI (JP)
OGO MAKOTO (JP)
HATAKEYAMA SHINJI (JP)
UENO MASATAKA (JP)
GROOM ANTHONY JOHN (GB)
RIVERS LEANNE (GB)
SMITH TERENCE (GB)
International Classes:
C07D237/14; C07D237/24; C07D401/04; C07D491/04; C07D491/048; C07D491/052; (IPC1-7): C07D237/04; C07D401/04; C07D237/14; C07D401/06; C07D409/04; C07D491/052; C07D491/048; C07D401/14; C07D405/14; C07D403/14; C07D409/14; C07D417/04; C07D253/06; A61K31/501; A61K31/50; A61K31/5025; A61K31/506; A61K31/53; A61K31/5377
Domestic Patent References:
| WO2000050408A1 | 2000-08-31 | |||
| WO1999044995A1 | 1999-09-10 |
Foreign References:
| US5426106A | 1995-06-20 | |||
| JP2000119257A | 2000-04-25 | |||
| JPH08225540A | 1996-09-03 | |||
| JPH05221992A | 1993-08-31 |
Other References:
LE PEILLET ET AL., BRAIN RES., vol. 571, 1992, pages 115
ZEA LONGA ET AL., STROKE, vol. 20, pages 84 - 91
See also references of EP 1319659A4
ZEA LONGA ET AL., STROKE, vol. 20, pages 84 - 91
See also references of EP 1319659A4
Attorney, Agent or Firm:
Furuya, Kaoru (Nihonbashi-Hamacho Chuo-ku, Tokyo, JP)
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