Title:
PYRIDINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO1999002497
Kind Code:
A3
Abstract:
Compounds of the formula (I), wherein X and R1 to R5 are as defined in the description, are useful for treating disorders mediated full or in part by mGluR5.
Inventors:
ALLGEIER HANS (DE)
AUBERSON YVES (CH)
BIOLLAZ MICHEL (CH)
COSFORD NICHOLAS DAVID (US)
GASPARINI FABRIZIO (CH)
HECKENDORN ROLAND (CH)
JOHNSON EDWIN CARL (US)
KUHN RAINER (DE)
VARNEY MARK ANDREW (US)
VELICELEBI GOENUEL (US)
AUBERSON YVES (CH)
BIOLLAZ MICHEL (CH)
COSFORD NICHOLAS DAVID (US)
GASPARINI FABRIZIO (CH)
HECKENDORN ROLAND (CH)
JOHNSON EDWIN CARL (US)
KUHN RAINER (DE)
VARNEY MARK ANDREW (US)
VELICELEBI GOENUEL (US)
Application Number:
PCT/EP1998/004266
Publication Date:
April 01, 1999
Filing Date:
July 09, 1998
Export Citation:
Assignee:
NOVARTIS AG (CH)
NOVARTIS ERFIND VERWALT GMBH (AT)
SIBIA NEUROSCIENCES INC (US)
ALLGEIER HANS (DE)
AUBERSON YVES (CH)
BIOLLAZ MICHEL (CH)
COSFORD NICHOLAS DAVID (US)
GASPARINI FABRIZIO (CH)
HECKENDORN ROLAND (CH)
JOHNSON EDWIN CARL (US)
KUHN RAINER (DE)
VARNEY MARK ANDREW (US)
VELICELEBI GOENUEL (US)
NOVARTIS ERFIND VERWALT GMBH (AT)
SIBIA NEUROSCIENCES INC (US)
ALLGEIER HANS (DE)
AUBERSON YVES (CH)
BIOLLAZ MICHEL (CH)
COSFORD NICHOLAS DAVID (US)
GASPARINI FABRIZIO (CH)
HECKENDORN ROLAND (CH)
JOHNSON EDWIN CARL (US)
KUHN RAINER (DE)
VARNEY MARK ANDREW (US)
VELICELEBI GOENUEL (US)
International Classes:
A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/4427; A61K31/443; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4709; A61K31/496; A61K31/497; A61K31/506; A61P9/10; A61P21/02; A61P21/04; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D213/16; C07D213/26; C07D213/30; C07D213/50; C07D213/52; C07D213/53; C07D213/55; C07D213/56; C07D213/57; C07D213/65; C07D213/74; C07D213/79; C07D213/80; C07D213/81; C07D213/82; C07D213/84; C07D213/89; C07D215/12; C07D401/06; C07D401/10; C07D401/12; C07D401/14; C07D405/06; C07D409/06; C07D413/06; C07F7/08; (IPC1-7): C07D213/65; A61K31/44; C07D213/80; C07D401/12; C07D401/06
Domestic Patent References:
| WO1997019049A1 | 1997-05-29 | |||
| WO1997005109A1 | 1997-02-13 |
Foreign References:
| EP0334119A1 | 1989-09-27 |
Other References:
DOWELL R.I.; HALES, N. H., TUCKER H.: "Novel inhibitors of prolyl 4-hydroxylase. Part 4. Pyridine-2-carboxylic acid analogues with alternative 2-substituents", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 28, no. 6, 1993, pages 513 - 516, XP002087215
LAZER E. S. ET AL: "Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 7, 1990, pages 1892 - 98, XP002087216
BAHNER, C. T. ET AL.: "Di- and tri-methoxystyryl derivatives of heterocyclic nitrogen compounds", ARZNEIM. FORSCH. / DRUG RES., vol. 31, no. 3, 1981, pages 404 - 6, XP002087217
HONMA Y; HANAMOTO K; HASHIYAMA T; SEKINE Y; TAKEDA M; ONO Y: "Antiallergic agents. 3. N-(1H-tetrazol-5-yl)-2-pyridinecarboxamides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 27, no. 2, 1984, pages 125 - 128, XP002087218
MORI M ET AL: "THE NEMATICIDAL ACTIVITY OF ACETYLENE COMPOUNDS", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 46, no. 1, 1982, pages 309 - 311, XP000645051
D. JERCHEL; H. E. HECK: "Kondensation von Methylpyridinen mit Benzaldehyd", JUSTUS LIEBIGS ANN. CHEM., vol. 613, 1958, pages 171 - 177, XP002087219
SADAO ARAI ET AL.: "Synthesis and reactions of methylbenzo[c]quinolizinium salts", JOURNAL OF HETEROCYCLIC CHEMISTRY, XP002087220
B.D. SHAW; E.A. WAGSTAFF: "The nitration of beta-phenylethylpyridines and related compounds", JOURNAL OF THE CHEMICAL SOCIETY, XP002087221
LAZER E. S. ET AL: "Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 7, 1990, pages 1892 - 98, XP002087216
BAHNER, C. T. ET AL.: "Di- and tri-methoxystyryl derivatives of heterocyclic nitrogen compounds", ARZNEIM. FORSCH. / DRUG RES., vol. 31, no. 3, 1981, pages 404 - 6, XP002087217
HONMA Y; HANAMOTO K; HASHIYAMA T; SEKINE Y; TAKEDA M; ONO Y: "Antiallergic agents. 3. N-(1H-tetrazol-5-yl)-2-pyridinecarboxamides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 27, no. 2, 1984, pages 125 - 128, XP002087218
MORI M ET AL: "THE NEMATICIDAL ACTIVITY OF ACETYLENE COMPOUNDS", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 46, no. 1, 1982, pages 309 - 311, XP000645051
D. JERCHEL; H. E. HECK: "Kondensation von Methylpyridinen mit Benzaldehyd", JUSTUS LIEBIGS ANN. CHEM., vol. 613, 1958, pages 171 - 177, XP002087219
SADAO ARAI ET AL.: "Synthesis and reactions of methylbenzo[c]quinolizinium salts", JOURNAL OF HETEROCYCLIC CHEMISTRY, XP002087220
B.D. SHAW; E.A. WAGSTAFF: "The nitration of beta-phenylethylpyridines and related compounds", JOURNAL OF THE CHEMICAL SOCIETY, XP002087221
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