PYRIDINE OR PYRIMIDINE DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF

Title:

PYRIDINE OR PYRIMIDINE DERIVATIVE AND PREPARATION METHOD THEREFOR AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2022/007869

Kind Code:

A1

Abstract:

The present invention relates to a pyridine or pyrimidine derivative, a preparation method therefor, and a medical use thereof. Specifically, the present invention relates to a pyridine or pyrimidine derivative as shown in general formula (I), a preparation method therefor, and a pharmaceutical salt thereof, and use of same as a therapeutic agent, especially the use of an SHP2 allosteric inhibitor. The definition of each substituent group in general formula (I) is the same as the definition in the description.

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Inventors:

HUANG XIANGUI (CN)
CAO QI (CN)
BIE PINGYAN (CN)
XING QINGNA (CN)
WANG XIN (CN)
YAN QINGYAN (CN)
LIAO WEIWEI (CN)
GUO YANGHUI (CN)
YE CHENG (CN)
HU TAISHAN (CN)
QIAN WENJIAN (CN)
CHEN LEI (CN)

Application Number:

PCT/CN2021/105100

Publication Date:

January 13, 2022

Filing Date:

July 08, 2021

Export Citation:

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Assignee:

ZHEJIANG HISUN PHARM CO LTD (CN)
HISUN ACCURAY THERAPEUTICS CO LTD (CN)

International Classes:

C07D401/04; A61K31/444; A61K31/4545; A61K31/506; A61P9/00; A61P27/02; A61P35/00; A61P35/02; A61P35/04; A61P37/00; C07D401/14; C07D403/04; C07D471/10; C07D487/08

Domestic Patent References:

WO2021143823A1	2021-07-22
WO2020181283A1	2020-09-10
WO2005085212A1	2005-09-15

Foreign References:

CN111212834A	2020-05-29
CN107787323A	2018-03-09
CN110431134A	2019-11-08

Other References:

DATABASE REGISTRY 29 September 2020 (2020-09-29), ANONYMOUS : " 4-Pyrimidinecarbonitrile, 6-amino-2-(4-amino-4-methyl-1-piperidinyl)-5- (2,3-dichlorophenyl)- (CA INDEX NAME) ", XP055885891, retrieved from STN Database accession no. 2488456-53-5

Attorney, Agent or Firm:

SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)

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