Title:
A PYRIDINYL SUBSTITUTED THIOHYDANTOIN PHARMACEUTICAL INTERMEDIATE AND ITS PREPARATION METHOD AND USE
Document Type and Number:
WIPO Patent Application WO/2024/022475
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of pharmaceutical synthesis technology and relates to a pyridyl-substituted thioglycolide intermediate for pharmaceutical use and its preparation method and use. In particular, the present invention discloses compounds of formula (I), which can be used to prepare thioglycolide drugs, and solves the defects of the existing process such as harsh conditions and low yields. The present invention also discloses various preparation methods of compounds of formula (I), which involve novel processes for some upstream intermediates (for example, compounds of formula (II) in the form of carboxylic acids). In addition, the present invention discloses for the first time a method for the synthesis of compounds of formula (I) to obtain thioglycolide analogues by ring closing reaction with aryl isothiocyanate.
Inventors:
TONG YOUZHI (CN)
MENG XIANGBING (CN)
ZHANG HUIHUI (CN)
XU RUO (CN)
MENG XIANGBING (CN)
ZHANG HUIHUI (CN)
XU RUO (CN)
Application Number:
PCT/CN2023/109790
Publication Date:
February 01, 2024
Filing Date:
July 28, 2023
Export Citation:
Assignee:
SUZHOU KINTOR PHARMACEUTICALS INC (CN)
International Classes:
C07D213/74; C07D413/06; C07D413/14
Domestic Patent References:
| WO2022161469A1 | 2022-08-04 |
Foreign References:
| CN103608333A | 2014-02-26 | |||
| US20120184580A1 | 2012-07-19 | |||
| CN103910679A | 2014-07-09 | |||
| CN104341351A | 2015-02-11 |
Other References:
ZHANG, QIONG-GUANG: "Graphical Synthetic Routes of Enzalutamide", STRAIT PHARMACEUTICAL, vol. 30, no. 12, 31 December 2018 (2018-12-31), XP055954893
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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