Title:
PYRIDINYLAMIDE DERIVATIVE, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/067709
Kind Code:
A1
Abstract:
Provided are a compound (I) or a pharmaceutically acceptable salt thereof, an ester thereof, an optical isomer thereof, a tautomer thereof, a stereoisomer thereof, a polymorph thereof, a solvate thereof, an N-oxide thereof, an isotopically labeled compound thereof, a metabolite thereof, a chelate thereof, a complex thereof, an inclusion compound thereof, or a prodrug thereof, and a pharmaceutical composition comprising the compound (I). Further provided are use of the compound as a 2α-type hypoxia inducible factor (HIF-2α) inhibitor and use of the compound in the preparation of a medicament for treating diseases related to the 2α-type hypoxia inducible factor.
More Like This:
Inventors:
LIU ZHIGUO (CN)
WU JIE (CN)
YE YANGLIANG (CN)
WANG HAO (CN)
WU JIE (CN)
YE YANGLIANG (CN)
WANG HAO (CN)
Application Number:
PCT/CN2023/122076
Publication Date:
April 04, 2024
Filing Date:
September 27, 2023
Export Citation:
Assignee:
SUZHOU ALPHAMA BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07D401/02; A61K31/454; A61K31/506; A61P35/00; A61P37/02; C07D285/00
Foreign References:
| CN112585119A | 2021-03-30 | |||
| CN114760994A | 2022-07-15 | |||
| CN111848572A | 2020-10-30 | |||
| CN105566321A | 2016-05-11 |
Other References:
DATABASE Registry CAS; ANONYMOUS , XP093151868, retrieved from STN
DATABASE CAS registry; ANONYMOUS : "C21 H24 N2 O3", XP093151858, retrieved from STN
DATABASE CAS STN; " 1-Azaspiro[4.4]nonane-3-carboxylic acid, 1-[(5-cyano-2-pyridinyl)carbonyl]- (CA INDEX NAME)", XP093151851, retrieved from REGISTRY
DATABASE REGISTER STN; ANONYMOUS : "Methanone, (4-hydroxy-1-azaspiro[4.4]non-1-yl)(3-hydroxy-2-pyridinyl)- (CA INDEX NAME)", XP093151854, retrieved from CAS
WITTEKIND RAYMOND R., WEISSMAN CARL, FARBER SHELDON, MELTZER ROBERT I.: "A polyphosphoric acid‐catalyzed spiroamidation. The conversion of N ‐[3‐(1‐cyclohexen‐1‐yl)propyl]‐2‐(3,4‐dimethoxyphenyl)acetamide to 1‐veratrylcarbonyl‐1‐azaspiro[4.5]decane", JOURNAL OF HETEROCYCLIC CHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 4, no. 1, 1 March 1967 (1967-03-01), US , pages 143 - 145, XP093151307, ISSN: 0022-152X, DOI: 10.1002/jhet.5570040130
DATABASE CAS registry; ANONYMOUS : "C21 H24 N2 O3", XP093151858, retrieved from STN
DATABASE CAS STN; " 1-Azaspiro[4.4]nonane-3-carboxylic acid, 1-[(5-cyano-2-pyridinyl)carbonyl]- (CA INDEX NAME)", XP093151851, retrieved from REGISTRY
DATABASE REGISTER STN; ANONYMOUS : "Methanone, (4-hydroxy-1-azaspiro[4.4]non-1-yl)(3-hydroxy-2-pyridinyl)- (CA INDEX NAME)", XP093151854, retrieved from CAS
WITTEKIND RAYMOND R., WEISSMAN CARL, FARBER SHELDON, MELTZER ROBERT I.: "A polyphosphoric acid‐catalyzed spiroamidation. The conversion of N ‐[3‐(1‐cyclohexen‐1‐yl)propyl]‐2‐(3,4‐dimethoxyphenyl)acetamide to 1‐veratrylcarbonyl‐1‐azaspiro[4.5]decane", JOURNAL OF HETEROCYCLIC CHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 4, no. 1, 1 March 1967 (1967-03-01), US , pages 143 - 145, XP093151307, ISSN: 0022-152X, DOI: 10.1002/jhet.5570040130
Attorney, Agent or Firm:
FIWIS INTELLECTUAL PROPERTY LAW FIRM (CN)
Download PDF: