Title:
PYRIDONOPYRIMIDINE DERIVATIVE AS RSK INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/056091
Kind Code:
A1
Abstract:
The present invention relates to a pyridonopyrimidine derivative as an RSK protein kinase inhibitor and use thereof. Specifically, the present invention relates to a compound represented by formula I, a pharmaceutical composition comprising the compound represented by formula I, and use of the compound in preparing a medicament for treating an RSK-related disease or inhibiting RSK. Formula I.
Inventors:
LI HONGLIN (CN)
LI SHILIANG (CN)
QIAN XUHONG (CN)
LIU KANGDONG (CN)
WANG ZHE (CN)
ZHAO ZHENJIANG (CN)
XU YUFANG (CN)
HE HUAN (CN)
LI SHILIANG (CN)
QIAN XUHONG (CN)
LIU KANGDONG (CN)
WANG ZHE (CN)
ZHAO ZHENJIANG (CN)
XU YUFANG (CN)
HE HUAN (CN)
Application Number:
PCT/CN2023/119237
Publication Date:
March 21, 2024
Filing Date:
September 15, 2023
Export Citation:
Assignee:
UNIV EAST CHINA NORMAL (CN)
UNIV EAST CHINA SCIENCE & TECH (CN)
UNIV ZHENGZHOU (CN)
JINFENG LABORATORY (CN)
UNIV EAST CHINA SCIENCE & TECH (CN)
UNIV ZHENGZHOU (CN)
JINFENG LABORATORY (CN)
International Classes:
C07D471/04; A61K31/519; A61P35/02; C07D475/00
Foreign References:
| CN1422268A | 2003-06-04 | |||
| CN113801118A | 2021-12-17 | |||
| CN108721298A | 2018-11-02 | |||
| CN113801139A | 2021-12-17 |
Other References:
VANDERWEL SCOTT N. ET AL.: "Pyrido[2,3-d]pyrimidin-7-ones as Specific Inhibitors of Cyclin-Dependent Kinase 4", J. MED. CHEM., vol. 48, no. 7, 3 February 2005 (2005-02-03), XP002540183, DOI: 10.1021/jm049355+
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF: