PYRIMIDINE COMPOUND

WIPO Patent Application WO/2005/037801

A1

Disclosed is a pyrimidine derivative with excellent MLR inhibitory effect or a pharmacologically acceptable salt thereof. Specifically, disclosed is a pyrimidine derivative represented by the general formula (I) below or a pharmacologically acceptable salt thereof. (I) (In the formula, R¹ represents a lower alkyl group; R² represents an aryl group or the like; A represents -NH- or the like; R³ represents -NHR⁶ group (wherein R⁶ represents an aryl group or the like) or the like; R⁴ represents a hydrogen atom or the like; and R⁵ represents a heterocyclic group or the like.)

TSURUOKA HIROYUKI
MATSUDA AKIHISA
SUGANO YUICHI
TATSUTA TORU

PCT/JP2004/015955

April 28, 2005

October 21, 2004

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SANKYO CO (JP)
TSURUOKA HIROYUKI
MATSUDA AKIHISA
SUGANO YUICHI
TATSUTA TORU

C07D401/12; (IPC1-7): C07D239/48; A61K31/505; A61K31/506; A61P1/04; A61P1/16; A61P3/10; A61P5/14; A61P7/06; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P21/04; A61P25/28; A61P27/16; A61P29/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D239/42; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07D403/14; C07D405/04; C07D405/12; C07D409/12; C07D409/14; C07D413/12

WO2003091223A1

2003-11-06

JPH05310717A

1993-11-22

DATABASE CAPLUS [online] DANAGUKYAN G.ET AL.: "Synthesis of methyl aryl ketone pyrimidinyl oximes and their reactions with nucleophiles", XP002983454, accession no. STN Database accession no. 1990:497560
DATABASE CAPLUS [online] DANAGULYAN G. ET AL.: "Synthesis of (2-oxopyrrolidinyl-1)pyrimidine derivatives", XP002983456, accession no. STN Database accession no. 1995:32119

Ohno, Akio c/o Sankyo Company (Limited 2-58, Hiromachi 1-chom, Shinagawa-ku Tokyo, JP)

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