Title:
PYRIMIDINE DERIVATIVE FUSED WITH NONAROMATIC RING
Document Type and Number:
WIPO Patent Application WO/2006/043490
Kind Code:
A1
Abstract:
A novel pyrimidine derivative, or pharmaceutically acceptable salt thereof, fused with a nonaromatic ring selected from among dihydrothiophene, dihydrofuran, a cycloalkyl, etc.; and a pharmaceutical composition comprising any of the above compounds as an active ingredient. These compounds exhibit excellent insulin secretion accelerating action and hyperglycemic action. Therefore, pharmaceutical compositions comprising the above compounds as an active ingredient due to the action thereof are useful in the therapy and/or prevention of insulin-dependent diabetes mellitus (type 1 diabetes), insulin-independent diabetes mellitus (type 2 diabetes), insulin resistant diseases, obesity, etc.
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Inventors:
YONETOKU YASUHIRO (JP)
NEGORO KENJI (JP)
ONDA KENICHI (JP)
HAYAKAWA MASAHIKO (JP)
SASUGA DAISUKE (JP)
NIGAWARA TAKAHIRO (JP)
IIKUBO KAZUHIKO (JP)
MORITOMO HIROYUKI (JP)
YOSHIDA SHIGERU (JP)
OHISHI TAKAHIDE (JP)
NEGORO KENJI (JP)
ONDA KENICHI (JP)
HAYAKAWA MASAHIKO (JP)
SASUGA DAISUKE (JP)
NIGAWARA TAKAHIRO (JP)
IIKUBO KAZUHIKO (JP)
MORITOMO HIROYUKI (JP)
YOSHIDA SHIGERU (JP)
OHISHI TAKAHIDE (JP)
Application Number:
PCT/JP2005/019000
Publication Date:
April 27, 2006
Filing Date:
October 17, 2005
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
YONETOKU YASUHIRO (JP)
NEGORO KENJI (JP)
ONDA KENICHI (JP)
HAYAKAWA MASAHIKO (JP)
SASUGA DAISUKE (JP)
NIGAWARA TAKAHIRO (JP)
IIKUBO KAZUHIKO (JP)
MORITOMO HIROYUKI (JP)
YOSHIDA SHIGERU (JP)
OHISHI TAKAHIDE (JP)
YONETOKU YASUHIRO (JP)
NEGORO KENJI (JP)
ONDA KENICHI (JP)
HAYAKAWA MASAHIKO (JP)
SASUGA DAISUKE (JP)
NIGAWARA TAKAHIRO (JP)
IIKUBO KAZUHIKO (JP)
MORITOMO HIROYUKI (JP)
YOSHIDA SHIGERU (JP)
OHISHI TAKAHIDE (JP)
International Classes:
C07D239/70; A61K31/517; A61K31/519; A61K31/5377; A61K31/55; A61K31/551; A61P3/10; C07D401/04; C07D401/12; C07D403/04; C07D403/12; C07D405/12; C07D417/12; C07D487/04; C07D491/048; C07D495/04
Domestic Patent References:
| WO2005014558A1 | 2005-02-17 | |||
| WO2004087056A2 | 2004-10-14 | |||
| WO2000031047A1 | 2000-06-02 | |||
| WO2000046214A1 | 2000-08-10 | |||
| WO2003049739A1 | 2003-06-19 |
Foreign References:
| JP2004509115A | 2004-03-25 | |||
| EP0276057B1 | 1994-03-09 |
Other References:
See also references of EP 1803710A4
Attorney, Agent or Firm:
Morita, Hiroshi c/o Astellas Pharma Inc. (Intellectual Property 3-11, Nihonbashi-Honcho 2-chom, Chuo-ku Tokyo 11, JP)
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