Title:
PYRIMIDINE DERIVATIVE INHIBITING GROWTH OF CANCER CELL AND MEDICINAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/256477
Kind Code:
A1
Abstract:
The present invention provides a novel pyrimidine derivative compound and a pharmaceutically acceptable salt thereof, each of which inhibits the growth of cancer cells. The present invention provides a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof. The present invention also provides a medicinal use of the pyrimidine derivative compound or a pharmaceutically acceptable salt thereof as an active ingredient for treatment of lung cancer. In addition, the present invention provides a method for treatment of lung cancer, the method comprising administering an effective amount of the compound according to the present invention, a salt thereof, or a composition comprising same to a subject in need thereof.
Inventors:
RYU HYUNG-CHUL (KR)
KIM JAE-SUN (KR)
KIM SUNG-EUN (KR)
LEE SUN-HO (KR)
LEE YONG-HYUB (KR)
KIM JAE-SUN (KR)
KIM SUNG-EUN (KR)
LEE SUN-HO (KR)
LEE YONG-HYUB (KR)
Application Number:
PCT/KR2020/007982
Publication Date:
December 24, 2020
Filing Date:
June 19, 2020
Export Citation:
Assignee:
ONCOBIX CO LTD (KR)
International Classes:
C07D239/48; A61K31/505; A61K31/506; A61K31/519; A61P35/00; C07D401/12; C07D403/12; C07D495/04
Domestic Patent References:
| WO2014124230A2 | 2014-08-14 |
Foreign References:
| US20170226065A1 | 2017-08-10 | |||
| KR20120047208A | 2012-05-11 | |||
| KR20180135815A | 2018-12-21 |
Other References:
JAEBONG JANG, JUNG BEOM SON, CIRIC TO, MAGDA BAHCALL, SO YOUNG KIM, SEOCK YONG KANG, MIERZHATI MUSHAJIANG, YOUNHO LEE, PASI A. JÄN: "Discovery of a potent dual ALK and EGFR T790M inhibitor", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 136, 1 August 2017 (2017-08-01), NL, pages 497 - 510, XP055766277, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.04.079
"Remington: The Science and Practice of Pharmacy", 2000, MACK PUBLISHING CO.
See also references of EP 3988542A4
"Remington: The Science and Practice of Pharmacy", 2000, MACK PUBLISHING CO.
See also references of EP 3988542A4
Attorney, Agent or Firm:
PHIL & ONZI INT'L PATENT & LAW FIRM (KR)
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