PYRIMIDINE DERIVATIVE

WIPO Patent Application WO/2006/123639

A1

A compound represented by the general formula (1) which has an inhibitory effect on PDE4 activity and produces little adverse side effects: wherein Ar¹ represents a furyl, thienyl, triazolyl, thiazolyl, oxazolyl or benzothiazolyl group; Ar² represents -E-AR²¹-G-Q (where Ar²¹ represents a benzene or naphthalene ring; E represents a single bond or an alkylene group; G represents a single bond, an alkylene group or an alkenylene group; and Q represents a carboxyl group, -CON(R⁴¹)(R⁴²) or -COOR⁴³), -E-Ar²¹-G²-G-Q (where E, Ar²¹, G and Q are as defined above; and G² represents -O-, -S-, -SO-, -SO²- or -NR^G21-) or a monocyclic aromatic heterocyclic ring other than a pyrazolyl group; R¹ and R² are the same as or different from each other and independently represent a hydrogen atom, an alkyl group which may be substituted or the like; and R³ represents a hydrogen atom or an alkyl group which may be substituted.

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NAGANUMA KENJI (JP)
YOKOI HIROTSUGU (JP)

PCT/JP2006/309713

November 23, 2006

May 16, 2006

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ASAHI KASEI PHARMA CORP (JP)
NAGANUMA KENJI (JP)
YOKOI HIROTSUGU (JP)

C07D405/04; A61K31/506; A61P1/04; A61P11/00; A61P11/02; A61P11/06; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P27/14; A61P29/00; A61P31/18; A61P37/06; A61P37/08; A61P43/00; C07D409/04; C07D417/04

WO2006037117A1	2006-04-06
WO2001083460A1	2001-11-08
WO2004014913A2	2004-02-19
WO2006004776A1	2006-01-12

JPH0789958A

1995-04-04

Kawaguchi, Yoshio (Jochi Kioizaka Bldg. 7-1 Kioi-ch, Chiyoda-ku Tokyo, JP)

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