Title:
PYRIMIDINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2002042280
Kind Code:
A3
Abstract:
The invention relates to compounds of the general formula (I) wherein R<1> is lower alkyl, lower alkoxy, pyridinyl, pyrimidinyl, phenyl, -S-lower alkyl, -S(O)2-lower alkyl, -N(R)-(CH2)n-N(R)2, -O-(CH2)n-N(R)2, -N(R)2, or a cyclic tertiary amine which may contain one additional heteroatom, selected from N, O or S, and wherein this group may be connected with the pyrimidine ring via the linker -O(CH2)n-; R<2> is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; R<3>/R<3'> is, independently from each other, hydrogen or lower alkyl; R<4> is independently from each other halogen, trifluoromethyl or lower alkoxy; X is-C(O)N(R) or -N(R)C(O)-; Y is -O-,-S-,-SO2-, or -N(R)-; n is 1,2,3 or 4; and m is 0,1 or 2; and to pharmaceutically acceptable acid addition salts thereof. They have a good affitity to the NK1 receptor and they are therefore suitable in the treatment of diseases, related to this receptor.
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Inventors:
STADLER HEINZ
Application Number:
PCT/EP2001/013084
Publication Date:
August 22, 2002
Filing Date:
November 13, 2001
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
International Classes:
A61K31/505; A61K31/506; A61K31/5377; A61K31/541; A61P1/04; A61P1/12; C07D239/36; A61P9/00; A61P11/06; A61P17/02; A61P19/02; A61P25/00; A61P25/04; A61P25/06; A61P25/16; A61P25/24; A61P25/30; A61P25/34; A61P27/02; A61P29/00; A61P35/00; C07D239/46; C07D239/47; C07D239/48; C07D239/52; C07D239/56; C07D401/04; (IPC1-7): C07D239/56; C07D239/46; C07D239/52; A61K31/505; A61P25/00; C07D401/04
Domestic Patent References:
| WO2001057025A1 | 2001-08-09 |
Foreign References:
| EP0257102A1 | 1988-03-02 |
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