Title:
PYRIMIDINE FUSED RING COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/061365
Kind Code:
A1
Abstract:
Provided are a compound represented by formula (I), or a tautomer, a cis-trans isomer, a mesomer, a racemate, an enantiomer, a diastereomer, or an atropisomer thereof, or a mixture form thereof, or a pharmaceutically acceptable salt, a solvate or a prodrug thereof, and use thereof as a selective inhibitor of KRAS mutation, and the compound has the advantages of high activity, good selectivity, low toxic and side effects, etc.
Inventors:
HUANG QI (CN)
HUANG WEI (CN)
LI SHENG (CN)
XIE JIAYU (CN)
HU HAI (CN)
XIONG YIHAO (CN)
WANG RUNFENG (CN)
WU XIAOQUAN (CN)
HUANG WEI (CN)
LI SHENG (CN)
XIE JIAYU (CN)
HU HAI (CN)
XIONG YIHAO (CN)
WANG RUNFENG (CN)
WU XIAOQUAN (CN)
Application Number:
PCT/CN2023/120882
Publication Date:
March 28, 2024
Filing Date:
September 22, 2023
Export Citation:
Assignee:
ORIGIANT PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D519/00; A61K31/407; A61K31/517; A61K31/519; A61P35/00; C07D239/72; C07D401/14; C07D403/14; C07D471/04
Domestic Patent References:
| WO2022192794A1 | 2022-09-15 | |||
| WO2022047260A1 | 2022-03-03 | |||
| WO2022173870A1 | 2022-08-18 | |||
| WO2022192790A1 | 2022-09-15 | |||
| WO2022228568A1 | 2022-11-03 | |||
| WO2023138583A1 | 2023-07-27 | |||
| WO2023125989A1 | 2023-07-06 | |||
| WO2023072188A1 | 2023-05-04 |
Attorney, Agent or Firm:
MERITS IP LTD. (CN)
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