Title:
PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/148243
Kind Code:
A1
Abstract:
Disclosed are a pyrimidine small-molecule compound and an application thereof. The pyrimidine small-molecule compound has efficient inhibitory activity towards PDGFRα and PDGFRβ kinases, but has relatively weak inhibitory activity towards other kinases. Therefore, the compound has very high selectivity and may be used as a potential drug for fighting tumors or relieving eye diseases, such as wet macular degeneration or uveitis.
Inventors:
LI XIAOKUN (CN)
LIU ZHIGUO (CN)
LIN LI (CN)
ZHENG XIAOHUI (CN)
QIAN JIANCHANG (CN)
LIU ZHIGUO (CN)
LIN LI (CN)
ZHENG XIAOHUI (CN)
QIAN JIANCHANG (CN)
Application Number:
PCT/CN2021/140401
Publication Date:
July 14, 2022
Filing Date:
December 22, 2021
Export Citation:
Assignee:
UNIV WENZHOU MEDICAL (CN)
International Classes:
C07D403/12; A61P27/02; A61P35/00; C07D239/48; C07D401/12; C07D495/04
Domestic Patent References:
| WO2017066428A1 | 2017-04-20 |
Foreign References:
| CN112778282A | 2021-05-11 | |||
| US20090054425A1 | 2009-02-26 | |||
| CN103626742A | 2014-03-12 | |||
| CN106831730A | 2017-06-13 | |||
| CN102112131A | 2011-06-29 | |||
| CN110669038A | 2020-01-10 | |||
| CN110746402A | 2020-02-04 | |||
| CN111423419A | 2020-07-17 | |||
| US20180290984A1 | 2018-10-11 |
Other References:
LIU, QIAN ET AL.: "A Novel Indazole Derivative, Compound Cyy-272, Attenuates LPS-Induced Acute Lung Injury by Inhibiting JNK Phosphorylation", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 428, 17 July 2021 (2021-07-17), XP086763374, DOI: 10.1016/j.taap.2021.115648
CHEN LINGFENG; FU WEITAO; FENG CHEN; QU RONG; TONG LINJIANG; ZHENG LULU; FANG BO; QIU YINDA; HU JIE; CAI YUEPIAO; FENG JIANPENG; X: "Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 140, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 510 - 527, XP085227230, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.08.061
DATABASE REGISTRY 8 June 2008 (2008-06-08), ANONYMOUS : "2,4-Pyrimidinediamine, 5-methyl-N4-(7-methyl-1H-indol-6-yl)-N2-[4-(4- methyl-1-piperazinyl)phenyl]-(CA INDEX NAME) ", XP055949169, retrieved from STN Database accession no. 1026199-28-9
CHEN LINGFENG; FU WEITAO; FENG CHEN; QU RONG; TONG LINJIANG; ZHENG LULU; FANG BO; QIU YINDA; HU JIE; CAI YUEPIAO; FENG JIANPENG; X: "Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 140, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 510 - 527, XP085227230, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2017.08.061
DATABASE REGISTRY 8 June 2008 (2008-06-08), ANONYMOUS : "2,4-Pyrimidinediamine, 5-methyl-N4-(7-methyl-1H-indol-6-yl)-N2-[4-(4- methyl-1-piperazinyl)phenyl]-(CA INDEX NAME) ", XP055949169, retrieved from STN Database accession no. 1026199-28-9
Attorney, Agent or Firm:
HANGZHOU ZHIXIAN PATENT AGENCY (CN)
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