Title:
PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS
Document Type and Number:
WIPO Patent Application WO1995014014
Kind Code:
A3
Abstract:
The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of baterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.
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Inventors:
DOMAGALA JOHN MICHAEL
ELLSWORTH EDMUND LEE
LUNNEY ELIZABETH
ORTWINE DANIEL FRED
PARA KIMBERLY SUZANNE
PRASAD JOSYULA VENKATA NAGENDR
SAWYER TOMI
TAIT BRADLEY DEAN
ELLSWORTH EDMUND LEE
LUNNEY ELIZABETH
ORTWINE DANIEL FRED
PARA KIMBERLY SUZANNE
PRASAD JOSYULA VENKATA NAGENDR
SAWYER TOMI
TAIT BRADLEY DEAN
Application Number:
PCT/US1994/012367
Publication Date:
June 15, 1995
Filing Date:
October 26, 1994
Export Citation:
Assignee:
PARKE DAVIS & CO (US)
International Classes:
A61K31/35; A61K31/351; A61K31/352; A61K31/365; A61K31/44; A61K31/443; C07D335/02; A61K31/48; A61P31/04; A61P31/12; C07D309/38; C07D309/40; C07D311/96; C07D405/04; C07D405/06; C07D405/10; C07D405/12; C07D407/04; C07D407/12; C07D409/04; C07D413/12; (IPC1-7): C07D309/38; C07D407/04; C07C325/52; A61K31/365; C07D335/02; C07D405/12
Domestic Patent References:
| WO1994011361A1 | 1994-05-26 |
Foreign References:
| FR3724M | ||||
| US3818046A | 1974-06-18 | |||
| EP0588137A1 | 1994-03-23 |
Other References:
CH.MENTZER ET AL.: "SYNTHESE DE NOUVEAUX DERIVES ALPHA-PYRONIQUES PAR CONDENSATION THERMIQUE D'ESTERS MALONIQUES AVEC DES CETONES.", BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, no. 75, 1962, PARIS FR, pages 365 - 369
CHEMICAL ABSTRACTS, vol. 78, no. 25, 1973, Columbus, Ohio, US; abstract no. 29482e, page 477;
CHEMICAL ABSTRACTS, vol. 78, no. 25, 1973, Columbus, Ohio, US; abstract no. 29482e, page 477;
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