Title:
PYROPTOSIS-INDUCED IMMUNOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2021/036793
Kind Code:
A1
Abstract:
Pyroptosis-induced immunotherapy is effected by activating a pore-forming, pyrpotogenic molecule, wherein the activating induces tumor cell pryoptosis and causes tumor regression by T-cell mediated anti-tumor immunity.
Inventors:
SHAO FENG (CN)
LIU ZHIBO (CN)
WANG QINYANG (CN)
WANG YUPENG (CN)
LIU ZHIBO (CN)
WANG QINYANG (CN)
WANG YUPENG (CN)
Application Number:
PCT/CN2020/108776
Publication Date:
March 04, 2021
Filing Date:
August 13, 2020
Export Citation:
Assignee:
NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN)
UNIV BEIJING (CN)
UNIV BEIJING (CN)
International Classes:
A61K45/00; A61P35/00
Domestic Patent References:
| WO2018049014A1 | 2018-03-15 | |||
| WO2018106753A1 | 2018-06-14 |
Other References:
WANG QINYANG; WANG YUPENG; DING JINGJIN; WANG CHUNHONG; ZHOU XUEHAN; GAO WENQING; HUANG HUANWEI; SHAO FENG; LIU ZHIBO: "A bioorthogonal system reveals antitumour immune function of pyroptosis", NATURE, MACMILLAN JOURNALS LTD., ETC, LONDON, vol. 579, no. 7799, 1 March 2020 (2020-03-01), London, pages 421 - 426, XP037069901, ISSN: 0028-0836, DOI: 10.1038/s41586-020-2079-1
KELLY DAVID R.ET AL.: "The Cleavage of t-Butyldimethylsilyl Ethers with Boron Trifluoride Etherate.", SYNTHETIC COMMUNICATIONS., vol. 9, no. 4, 31 December 1979 (1979-12-31), pages 295 - 299, XP009526315, DOI: 10.1080/00397917908064155
SHI JIANJIN; GAO WENQING; SHAO FENG: "Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death", TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER, AMSTERDAM, NL, vol. 42, no. 4, 5 December 2016 (2016-12-05), AMSTERDAM, NL, pages 245 - 254, XP029956975, ISSN: 0968-0004, DOI: 10.1016/j.tibs.2016.10.004
LI JIE, CHEN PENG R: "Development and application of bond cleavage reactions in bioorthogonal chemistry", NATURE CHEMICAL BIOLOGY, NATURE PUB. GROUP, NEW YORK, vol. 12, no. 3, 1 March 2016 (2016-03-01), New York, pages 129 - 137, XP055785593, ISSN: 1552-4450, DOI: 10.1038/nchembio.2024
KELLY DAVID R.ET AL.: "The Cleavage of t-Butyldimethylsilyl Ethers with Boron Trifluoride Etherate.", SYNTHETIC COMMUNICATIONS., vol. 9, no. 4, 31 December 1979 (1979-12-31), pages 295 - 299, XP009526315, DOI: 10.1080/00397917908064155
SHI JIANJIN; GAO WENQING; SHAO FENG: "Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death", TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER, AMSTERDAM, NL, vol. 42, no. 4, 5 December 2016 (2016-12-05), AMSTERDAM, NL, pages 245 - 254, XP029956975, ISSN: 0968-0004, DOI: 10.1016/j.tibs.2016.10.004
LI JIE, CHEN PENG R: "Development and application of bond cleavage reactions in bioorthogonal chemistry", NATURE CHEMICAL BIOLOGY, NATURE PUB. GROUP, NEW YORK, vol. 12, no. 3, 1 March 2016 (2016-03-01), New York, pages 129 - 137, XP055785593, ISSN: 1552-4450, DOI: 10.1038/nchembio.2024
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (CN)
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