PYRROLOBENZODIAZEPINES AS KEY INTERMEDIATES IN THE SYNTHESIS OF DIMERIC CYTOTOXIC PYRROLOBENZODIAZEPINES

Title:

PYRROLOBENZODIAZEPINES AS KEY INTERMEDIATES IN THE SYNTHESIS OF DIMERIC CYTOTOXIC PYRROLOBENZODIAZEPINES

Document Type and Number:

WIPO Patent Application WO2005085259

Kind Code:

Abstract:

Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R

More Like This:

WO/1998/045288	TREATMENT OR PROPHYLAXIS OF PROSTATIC CANCER AND BENIGN PROSTATIC HYPERPLASIA WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS
WO/2003/096989	ANTI TUBERCULAR DRUG: COMPOSITIONS AND METHODS
JP2003519143	INDUSTRIAL APPLICABILITY: Pyrimidine and triazine kinase inhibitors

Inventors:

HOWARD PHILIP WILSON (GB)
KANG GYOUNG-DONG (GB)

Application Number:

PCT/GB2005/000770

Publication Date:

January 05, 2006

Filing Date:

March 01, 2005

Export Citation:

Click for automatic bibliography generation Help

Assignee:

SPIROGEN LTD (GB)
HOWARD PHILIP WILSON (GB)
KANG GYOUNG-DONG (GB)

International Classes:

A61K31/55; C07D487/04; C07D519/00; (IPC1-7): C07D519/00; C07D487/04; A61K31/55; A61P35/00

Domestic Patent References:

WO2000012508A2	2000-03-09
WO2000012507A2	2000-03-09

Foreign References:

US20030187253A1

2003-10-02

Other References:

GREGSON S J ET AL: "Linker Length Modulates DNA Cross-Linking Reactivity and Cytotoxic Potency of C8/C8' Ether-Linked C2-exo-Unsaturated Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Dimers", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 47, 30 January 2004 (2004-01-30), pages 1161 - 1174, XP002316295, ISSN: 0022-2623
KAMAL A ET AL: "Synthesis and DNA-binding affinity of A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 13, no. 22, 14 October 2003 (2003-10-14), pages 3955 - 3958, XP002329064, ISSN: 0960-894X

Download PDF:

View/Download PDF PDF Help

Previous Patent: 3-PYRIDINIUM METHYLCEPHEM COMPOUND

Next Patent: PROCESS FOR PRODUCING AMINOPHOSPHONIC ACID DERIVATIVE